41 Result(s)

Article

Purine salvage–associated metabolites as biomarkers for early diagnosis of esophageal squamous cell carcinoma: a diagnostic model–based study

Esophageal squamous cell carcinoma (ESCC) remains an important health concern in develo** countries. Patients with advanced ESCC have a poor prognosis and survival rate, and achieving early diagnosis remains...

Yawen Sun, Wenjuan Liu, Mu Su, Tao Zhang, **a Li, Wenbin Liu… in Cell Death Discovery (2024)

Article

Correction: Involvement of FSP1-CoQ₁₀-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis

Ming Yang, Michelle Grace Tsui, Jessica Kwan Wun Tsang… in Cell Death & Disease (2024)

Article

Loss of LECT2 promotes ovarian cancer progression by inducing cancer invasiveness and facilitating an immunosuppressive environment

Leukocyte cell-derived chemotaxin 2 (LECT2) is a multifunctional cytokine that can bind to several receptors and mediate distinct molecular pathways in various cell settings. Changing levels of LECT2 have been...

Chin-Jui Wu, Ke-Fan Pan, Ji-Qing Chen, Yu -Chen Tao, Yu-Cheng Liu, Bo-Rong Chen… in Oncogene (2024)

Article

Systemic inflammation and insulin resistance-related indicator predicts poor outcome in patients with cancer cachexia

The C-reactive protein (CRP)-triglyceride-glucose (TyG) index (CTI), which is a measure representing the level of inflammation and insulin resistance (IR), is related to poor cancer prognosis; however, the CTI...

Guo-Tian Ruan, Li Deng, Hai-Lun **e, **-Yu Shi, **ao-Yue Liu… in Cancer & Metabolism (2024)

Article

PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy

Autophagy of endoplasmic reticulum (ER-phagy) selectively removes damaged ER through autophagy-lysosome pathway, acting as an adaptive mechanism to alleviate ER stress and restore ER homeostasis. However, the ...

**fei Yang, Li Li, Chenrui Li, Wei Chen, Yan Liu, Shilu Luo… in Cell Death & Disease (2023)

Article

Altered cfDNA fragmentation profile in hypomethylated regions as diagnostic markers in breast cancer

Breast cancer, the most common malignancy in women worldwide, has been proven to have both altered plasma cell-free DNA (cfDNA) methylation and fragmentation profiles. Nevertheless, simultaneously detecting bo...

Jun Wang, Yanqin Niu, Ming Yang, Lirong Shu, Hongxian Wang… in Epigenetics & Chromatin (2023)

Article

Correction: Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy

Min Yang, Bo Tang, Sumin Wang, Li Tang, Dalin Wen, Israel Vlodavsky… in Oncogenesis (2023)

Article

Characterization of mesenchymal stem cells in human fetal bone marrow by single-cell transcriptomic and functional analysis

Bone marrow mesenchymal stromal/stem cells (MSCs) are a heterogeneous population that can self-renew and generate stroma, cartilage, fat, and bone. Although a significant progress has been made toward recogniz...

** Zhang, Ji Dong, **aoying Fan, Jun Yong… in Signal Transduction and Targeted Therapy (2023)

Article

The RXFP2-PLC/PKC signaling pathway mediates INSL3-induced regulation of the proliferation, migration and apoptosis of mouse gubernacular cells

Testicular hypoplasia can affect the sexual and reproductive ability in adulthood, and even increase the risk of cancer. Abnormal development of the gubernaculum is one of the important factors of testicular h...

Shouxing Duan, Xuewu Jiang, Jianhong Li, Maxian Fu… in Cellular & Molecular Biology Letters (2023)

Article

Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants: a randomized phase 2 trial

An ongoing randomized, double-blind, controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate, named NVSI-06-09, as a booster dose in subj...

Nawal Al Kaabi, Yun Kai Yang, Yu Liang, Ke Xu… in Signal Transduction and Targeted Therapy (2023)

Article

COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan

The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by ...

Hong Liang, Xuanxuan Nian, Junzheng Wu, Dong Liu, Lu Feng, Jia Lu… in Cell Discovery (2022)

Article

Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1

The cyclin-dependent kinase 7 (CDK7) inhibitor THZ1 represses multiple cancer cells. However, its tumor-repressive efficiency in wild-type p53 breast cancer cells remains controversial.

Yueyuan Wang, Zhihao Zhang, Xuguang Mi, Mingxi Li… in Cell Communication and Signaling (2022)

Article

Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy

Heparanase (HPA) is the predominant enzyme that cleaves heparan sulfate and plays a critical role in a variety of pathophysiological processes. HPA activity has been traditionally correlated with tumor metasta...

Min Yang, Bo Tang, Sumin Wang, Li Tang, Dalin Wen, Israel Vlodavsky… in Oncogenesis (2022)

Article

Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV: a phase 2 trial

The increased coronavirus disease 2019 (COVID-19) breakthrough cases pose the need of booster vaccination. We conducted a randomised, double-blinded, controlled, phase 2 trial to assess the immunogenicity and ...

Nawal Al Kaabi, Yun Kai Yang, **g Zhang, Ke Xu… in Signal Transduction and Targeted Therapy (2022)

Article

Correction to: Sox10 Gene Is Required for the Survival of Saccular and Utricular Hair Cells in a Porcine Model

**g-cui Qi, Qing-qing Jiang, Long Ma, Shuo-long Yuan, Wei Sun… in Molecular Neurobiology (2022)

Article

Involvement of FSP1-CoQ₁₀-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis

Retinal pigment epithelium (RPE) degeneration plays an important role in a group of retinal disorders such as retinal degeneration (RD) and age-related macular degeneration (AMD). The mechanism of RPE cell dea...

Ming Yang, Michelle Grace Tsui, Jessica Kwan Wun Tsang… in Cell Death & Disease (2022)

Article

miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD⁺/SIRT inactivation

Nicotinamide adenine dinucleotide (NAD⁺) is indispensable for the anti-aging activity of the sirtuin (SIRT) family enzymes. AMP-activated protein kinase (AMPK) upregulates NAD⁺ synthesis and SIRT activity in a ni...

Hui Gong, Honghan Chen, Peng **ao, Ning Huang… in Signal Transduction and Targeted Therapy (2022)

Article

YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner

N6-methyladenosine (m⁶A) is the most common post-transcriptional modification at the RNA level. However, the exact molecular mechanisms of m6A epigenetic regulation in breast cancer remain largely unknown and nee...

Hengyu Chen, Yuanhang Yu, Ming Yang, Haohao Huang, Shenghui Ma, ** Hu… in Cell & Bioscience (2022)

Article

Application of stem cells in the repair of intervertebral disc degeneration

Intervertebral disc degeneration (IDD) is a common disease that increases with age, and its occurrence is stressful both psychologically and financially. Stem cell therapy for IDD is emerging. For this therapy...

Wentao Zhang, Tianze Sun, Ying Li, Ming Yang, Yantao Zhao… in Stem Cell Research & Therapy (2022)

Article

LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1

Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are effective targeted therapy drugs for advanced non-small cell lung cancer (NSCLC) patients carrying sensitized EGFR mutations. The rapi...

Yankang Li, Yue Shen, Mengyu **e, Bowen Wang… in Signal Transduction and Targeted Therapy (2022)