14 Result(s)
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Article
Michael J. Hannon
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Article
Open AccessMetallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo
Shape-selective recognition of nucleic acid structures by supramolecular drugs offers the potential to treat disease. The Trans Activation Response (TAR) region is a region of high secondary structure within t...
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Partial meniscectomy is associated with increased risk of incident radiographic osteoarthritis and worsening cartilage damage in the following year
To assess whether partial meniscectomy is associated with increased risk of radiographic osteoarthritis (ROA) and worsening cartilage damage in the following year.
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Open AccessIron(II) supramolecular helicates interfere with the HIV-1 Tat–TAR RNA interaction critical for viral replication
The interaction between the HIV-1 transactivator protein Tat and TAR (transactivation responsive region) RNA, plays a critical role in HIV-1 transcription. Iron(II) supramolecular helicates were evaluated for ...
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Comparison of radiographic joint space width and magnetic resonance imaging for prediction of knee replacement: A longitudinal case-control study from the Osteoarthritis Initiative
To evaluate whether change in fixed-location measures of radiographic joint space width (JSW) and cartilage thickness by MRI predict knee replacement.
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Open AccessDeterminants of patient preferences for total knee replacement: African-Americans and whites
Patient preferences contribute to marked racial disparities in the utilization of total knee replacement (TKR). The objectives of this study were to identify the determinants of knee osteoarthritis (OA) patien...
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Open AccessPrevalence of MRI-detected mediopatellar plica in subjects with knee pain and the association with MRI-detected patellofemoral cartilage damage and bone marrow lesions: data from the Joints On Glucosamine study
The mediopatellar plica is a synovial fold representing an embryonic remnant from the developmental process of the synovial cavity formation in the knee. We aimed to examine the frequency of MRI-detected medio...
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Perceived Racial Discrimination in Health Care and Race Differences in Physician Trust
Racial discrimination in health care is more often perceived by racial minority patients than by whites. In this study, we explored whether two types of perceived racial discrimination, perceptions that the he...
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Open AccessModifications of the metabolic pathways of lipid and triacylglycerol production in microalgae
Microalgae have presented themselves as a strong candidate to replace diminishing oil reserves as a source of lipids for biofuels. Here we describe successful modifications of terrestrial plant lipid content w...
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Open AccessSemiquantitative assessment of subchondral bone marrow edema-like lesions and subchondral cysts of the knee at 3T MRI: A comparison between intermediate-weighted fat-suppressed spin echo and Dual Echo Steady State sequences
Choice of appropriate MR pulse sequence is important for any research studies using imaging-derived data. The aim of this study was to compare semiquantitative assessment of subchondral bone marrow edema-like ...
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Open AccessLongitudinal assessment of cyst-like lesions of the knee and their relation to radiographic osteoarthritis and MRI-detected effusion and synovitis in patients with knee pain
The purpose of the present study was to determine the prevalence of cystic lesions and cyst-like bursitides in subjects with frequent knee pain and to assess their relation to radiographic osteoarthritis (OA) ...
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Electron capture dissociation mass spectrometry of metallo-supramolecular complexes
The electron capture dissociation (ECD) of metallo-supramolecular dinuclear triple-stranded helicate Fe2L 3 4+ ions was determined by Fourier transform ion cyc...
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Open AccessRuthenium polypyridyl complexes and their modes of interaction with DNA: Is there a correlation between these interactions and the antitumor activity of the compounds?
Various interaction modes between a group of six ruthenium polypyridyl complexes and DNA have been studied using a number of spectroscopic techniques. Five mononuclear species were selected with formula [Ru(tpy)L
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Interaction between a DNA oligonucleotide and a dinuclear iron(II) supramolecular cylinder; an NMR and molecular dynamics study
A tetracationic supramolecular cylinder, [Fe2L3]4+ (L=C25H20N4), with a triple-helical architecture, is just the right size to fit into the major groove of DNA but too big to fit into the minor groove. A detaile...
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Report: Past and Present Insurance Coverage in a Public Sector Community Mental Health Population
