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1,431 Result(s)
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Article
Jackknife Model Averaging for Composite Quantile Regression
In this paper, the authors propose a frequentist model averaging method for composite quantile regression with diverging number of parameters. Different from the traditional model averaging for quantile regres...
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Combining multimodal diffusion-weighted imaging and morphological parameters for detecting lymph node metastasis in cervical cancer
Accurate detection of lymph node metastasis (LNM) is crucial for determining the tumor stage, selecting optimal treatment, and estimating the prognosis for cervical cancer. This study aimed to assess the diagn...
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Neural substrates for regulating self-grooming behavior in rodents
Grooming, as an evolutionarily conserved repetitive behavior, is common in various animals, including humans, and serves essential functions including, but not limited to, hygiene maintenance, thermoregulation...
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Open AccessBNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC
An increasing evidence supports that cell competition, a vital selection and quality control mechanism in multicellular organisms, is involved in tumorigenesis and development; however, the mechanistic contrib...
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Open AccessStable peptide-assembled nanozyme mimicking dual antifungal actions
Natural antimicrobial peptides (AMPs) and enzymes (AMEs) are promising non-antibiotic candidates against antimicrobial resistance but suffer from low efficiency and poor stability. Here, we develop peptide nan...
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GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma
Despite significantly improved clinical outcomes in EGFR-mutant lung adenocarcinoma, all patients develop acquired resistance and malignancy on the treatment of EGFR tyrosine kinase inhibitors (EGFR-TKIs). Und...
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Open AccessClinical serum lipidomic profiling revealed potential lipid biomarkers for early diabetic retinopathy
Diabetic retinopathy (DR) is a serious complication of diabetes featuring abnormal lipid metabolism. However, the specific lipid molecules associated with onset and progression remain unclear. We used a broad-...
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Identification of potential PIM-2 inhibitors via ligand-based generative models, molecular docking and molecular dynamics simulations
Proviral Integrations of Moloney-2 (PIM-2) kinase is a promising target for various cancers and other diseases, and its inhibitors hold potential for treating related diseases. However, there is currently no c...
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Zein–natamycin functional films with ethylene adsorption and fungi stasis for active food packaging applications
The main factors that lead to fruit spoilage are ethylene and microbial contamination. The majority of existing studies focus on single regulation tools for extending fruit shelf life, such as controlling ethy...
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Overcoming genotypic dependency and bypassing immature embryos in wheat transformation by using morphogenic regulators
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Clean Coloration and Antibacterial-Finishing of Angora Wool Fabric Using Natural Dye-Aided Tannic Acid Mordanting by Electrospray
Currently, the dyeing processes between natural fibers and dyes heavily rely on inorganic electrolytes, posing significant challenges to ecological and sustainable development. In this work, zinc ion was used ...
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Research on ultrasonic elliptical vibration-assisted cutting system based on double excitation
Hard and brittle alloy materials are of great importance in critical fields such as aerospace, military, and semiconductors. To address the challenges encountered in machining hard and brittle materials, a pro...
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(3-Aminopropyl)trimethoxysilane-Assisted Co-assembly to Monolithic Pd@SiO2/Al2O3/Al Catalysts for Low Concentration CH4 Combustion: Effect of Preparation Conditions
Herein, an affordable strategy was developed to form Pd@SiO2 nanostructure assembled onto monolithic AlOOH/Al nanoarrays from nano- to macro-scale by a one-step reaction process. (3-Aminopropyl)trimethoxysilane (...
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A review on the laser-induced synthesis of graphene and its applications in sensors
Graphene, due to its unique zero-bandgap, single-layer structure, and outstanding properties, has attracted more than a decade of research interests. In the upstream of graphene research, laser manufacturing w...
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CH3COOLi-assisted lithium source on the synthesis of high-performance single-crystal Ni-rich cathode material
Layered nickel-rich oxides, Li(NixCoyMn1–x–y)O2 (x ≥ 0.6), exhibit a high reversible capacity of over 200 mAh/g, ranking as one of the greatest attractive cathode materials for lithium-ion batteries. Nevertheless...
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Global–local Bi-alignment for purer unsupervised domain adaptation
Unsupervised domain adaptation (UDA) aims to extract domain-invariant features. Existing UDA methods mainly utilize a convolutional neural network (CNN) or vision transformer (ViT) as feature extractor, which ...
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Lysosomal cation channel TRPML1 suppression sensitizes acute myeloid leukemia cells to chemotherapeutics by inhibiting autophagy
Despite the implementation of novel therapeutic regimens and extensive research efforts, chemoresistance remains a formidable challenge in the treatment of acute myeloid leukemia (AML). Notably, the involvemen...
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Open AccessFacet-selective growth of halide perovskite/2D semiconductor van der Waals heterostructures for improved optical gain and lasing
The tunable properties of halide perovskite/two dimensional (2D) semiconductor mixed-dimensional van der Waals heterostructures offer high flexibility for innovating optoelectronic and photonic devices. Howeve...
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Strengthening cement paste via organic-inorganic network formation
The inherent brittleness of cement hydrates poses a major issue to the mechanical and durable performances of concrete. To conquer this issue, we constructed an organic–inorganic network within the cement matr...
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Open AccessMultiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis
Monocyte-derived alveolar macrophages (Mo_AMs) are increasingly recognised as potential pathogenic factors for idiopathic pulmonary fibrosis (IPF). While scRNAseq analysis has proven valuable in the transcript...