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  1. Article

    Open Access

    Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression

    Spreading depression (SD) is an intriguing phenomenon characterized by massive slow brain depolarizations that affect neurons and glial cells. This phenomenon is repetitive and produces a metabolic overload th...

    Juan E. Tichauer, Matías Lira, Waldo Cerpa, Juan A. Orellana… in Biological Research (2024)

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  2. Article

    Open Access

    Exo70 intracellular redistribution after repeated mild traumatic brain injury

    Exo70 is a subunit of the greater exocyst complex, a collection of proteins that oversees cellular membrane addition and polarized exocytosis by acting as a tethering intermediate between the plasma membrane a...

    Matías Lira, Pedro Zamorano, Waldo Cerpa in Biological Research (2021)

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  3. No Access

    Article

    The Exocyst Component Exo70 Modulates Dendrite Arbor Formation, Synapse Density, and Spine Maturation in Primary Hippocampal Neurons

    Neurons are highly polarized cells displaying an elaborate architectural morphology. The design of their dendritic arborization and the distribution of their synapses contribute importantly to information proc...

    Matías Lira, Duxan Arancibia, Patricio R. Orrego… in Molecular Neurobiology (2019)