1 Result(s)

Article

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

The new entry inhibitor eCD4-Ig, consisting of the immunoadhesin form of CD4 (CD4-Ig) fused to a small CCR5-mimetic sulfopeptide, avidly binds two highly conserved sites of the HIV-1 Env protein; the inhibitor...

Matthew R. Gardner, Lisa M. Kattenhorn, Hema R. Kondur, Markus von Schaewen… in Nature (2015)