6 Result(s)
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Article
Population pharmacokinetics of rosuvastatin in pediatric patients with heterozygous familial hypercholesterolemia
Data from two clinical studies (hyperCholesterolaemia in cHildren and Adolescents taking Rosuvastatin OpeN label [CHARON; NCT01078675] and Study 4522IL/0086) were used to describe rosuvastatin pharmacokinetics...
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Article
Open AccessLong-Term Statin Treatment in Children with Familial Hypercholesterolemia: More Insight into Tolerability and Adherence
Statins are currently the preferred pharmacological therapy in individuals with familial hypercholesterolemia (FH) with the aim to prevent premature atherosclerosis. In adults, these agents have been proven to...
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Article
Management of Hypercholesterolemia in Children
Cardiovascular disease (CVD) remains the leading cause of death and morbidity in our society. One of the major risk factors for CVD is hypercholesterolemia. Hypercholesterolemia in children can be caused by a ...
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Article
Familial Hypercholesterolemia: Advances in Understanding the Early Natural History
Familial hypercholesterolemia (FH) is a very common inherited disorder of lipoprotein metabolism, associated with increased cholesterol levels from birth onwards and premature coronary artery disease. In order...
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Article
Drug Therapy of Hypercholesterolaemia in Children and Adolescent
Cardiovascular disease (CVD) remains the leading cause of death and morbidity in the world. The origins of atherosclerosis and subsequent CVD begin in childhood. In order to prevent CVD, children and adolescen...
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Article
Open AccessClinical practice
Protein-losing enteropathy (PLE) is a rare complication of a variety of intestinal disorders characterized by an excessive loss of proteins into the gastrointestinal tract due to impaired integrity of the muco...
