6 Result(s)
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Article
Open AccessDifferential vulnerability of hippocampal CA3-CA1 synapses to Aβ
Amyloid-beta (Aβ) and tau protein are both involved in the pathogenesis of Alzheimer’s disease. Aβ produces synaptic deficits in wild-type mice that are not seen in Mapt−/− mice, suggesting that tau protein is re...
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Article
Open AccessTau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease
Multimerization is a key process in prion-like disorders such as Alzheimer’s disease (AD), since it is a requirement for self-templating tau and beta-amyloid amyloidogenesis. AT8-immunohistochemistry for hyper...
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Article
Open AccessA primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain
Glutamate receptors of the N-methyl-D-aspartate (NMDA) family are coincident detectors of pre- and postsynaptic activity, allowing Ca2+ influx into neurons. These properties are central to neurological disease me...
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Article
Open AccessEmergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease
The synaptic changes underlying the onset of cognitive impairment in Alzheimer’s disease (AD) are poorly understood. In contrast to the well documented inhibition of long-term potentiation (LTP) in CA3-CA1 syn...
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Article
Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex
Glutamate NMDA receptors are involved in pain signaling, but inhibiting them would have too many side effects. These authors show that inhibiting the binding of NMDA receptors to Src, a molecule that is respos...
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Article
Visual stimuli–induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors
Local GABA (γ-aminobutyric acid) circuits contribute to sensory experience–dependent refinement of neuronal connections in the develo** nervous system, but whether GABAergic synapses themselves can be rapidl...
