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Open AccessElectrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors
Polyamines have fundamental roles in brain homeostasis as key modulators of cellular excitability. Several studies have suggested alterations in polyamine metabolism in stress related disorders, suicide, depre...
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Article
Erratum: Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder
Correction to: Translational Psychiatry (2015) 5, e636; doi:10.1038/tp.2015.134; published online 15 September 2015 In the Acknowledgments section, the funding through The Brain & Behavior Research Foundation ...
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Open AccessA genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder
Elevated cerebrospinal fluid (CSF) levels of the glia-derived N-methyl-D-aspartic acid receptor antagonist kynurenic acid (KYNA) have consistently been implicated in schizophrenia and bipolar disorder. Here, we c...
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Article
Open AccessVariable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder
Stress can be a predisposing factor to psychiatric disorders and has been associated with decreased neurogenesis and reduced hippocampal volume especially in depression. Similarly, in white blood cells chronic...
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Article
Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder
Conventional antidepressants require 2–8 weeks for a full clinical response. In contrast, two rapidly acting antidepressant interventions, low-dose ketamine and sleep deprivation (SD) therapy, act within hours...
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Article
The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression
The kynurenine pathway metabolite kynurenic acid (KYNA), modulating glutamatergic and cholinergic neurotransmission, is increased in cerebrospinal fluid (CSF) of patients with schizophrenia or bipolar disorder...
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Article
Coding SNPs included in exon arrays for the study of psychiatric disorders
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Mitochondrial related gene expression changes are sensitive to agonal-pH state
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Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders
Mitochondrial defects in gene expression have been implicated in the pathophysiology of bipolar disorder and schizophrenia. We have now contrasted control brains with low pH versus high pH and showed that 28% ...
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Article
Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse
CNS-focused cDNA microarrays were used to examine gene expression profiles in dorsolateral prefrontal cortex (dlPFC, Area 46) from seven individual sets of age- and post-mortem interval-matched male cocaine ab...
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Article
Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia
Several studies suggest that decreased expression of presynaptic proteins may be characteristic of schizophrenia. We examined one such protein, synapsin, in schizophrenia and bipolar disorder. Samples of hippo...
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Article
Alterations of hippocampal secreted N-CAM in bipolar disorder and synaptophysin in schizophrenia
Schizophrenia and bipolar disorder have both been linked to structural abnormalities of the hippocampus, which is consistent with a neurodevelopmental anomaly. One isoform of the neural cell adhesion molecule ...
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Article
Immunohistochemical localization of the cell adhesion molecules Thy-1 and L1 in the human prefrontal cortex: patients with schizophrenia, bipolar disorder, and depression
L1 and Thy-1 are members of the immunoglobulin (Ig) superfamily of cell adhesion molecules (CAMs) that are vital for normal neural development. Abnormalities in CAM expression could lead to the histological ab...
