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  1. No Access

    Article

    Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation

    Class IA phosphatidylinositol 3-kinases (PI3Ks) are composed of p110 catalytic and p85 regulatory subunits. How regulatory subunits modulate PI3K activity remains only partially understood. Here we identified ...

    C F de la Cruz-Herrera, M Baz-Martínez, V Lang, A El Motiam, J Barbazán… in Oncogene (2016)

  2. Article

    Open Access

    Regulation of the tumor suppressor PTEN by SUMO

    The crucial function of the PTEN tumor suppressor in multiple cellular processes suggests that its activity must be tightly controlled. Both, membrane association and a variety of post-translational modificati...

    J González-Santamaría, M Campagna, A Ortega-Molina, L Marcos-Villar… in Cell Death & Disease (2012)

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  3. Article

    SIRT1 stabilizes PML promoting its sumoylation

    SIRT1, the closest mammalian homolog of yeast Sir2, is an NAD+-dependent deacetylase with relevant functions in cancer, aging, and metabolism among other processes. SIRT1 has a diffuse nuclear localization but is...

    M Campagna, D Herranz, M A Garcia, L Marcos-Villar… in Cell Death & Differentiation (2011)

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  4. No Access

    Article

    Role of mitochondria in apoptosis induced by the 2‐5A system and mechanisms involved

    The 2‐5A system (2-5OAS/RNaseL) is composed of the 2′,5′oligoadenylate synthetase 1 (2-5OAS1) and 2-5A-dependent RNase (RNaseL), enzymes that play a key role in antiviral defence mechanisms. Activation of the ...

    E. Domingo-Gil, M. Esteban in Apoptosis (2006)