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    Article

    Conjugation of SUMO to p85 leads to a novel mechanism of PI3K regulation

    Class IA phosphatidylinositol 3-kinases (PI3Ks) are composed of p110 catalytic and p85 regulatory subunits. How regulatory subunits modulate PI3K activity remains only partially understood. Here we identified ...

    C F de la Cruz-Herrera, M Baz-Martínez, V Lang, A El Motiam, J Barbazán… in Oncogene (2016)

  2. Article

    SIRT1 stabilizes PML promoting its sumoylation

    SIRT1, the closest mammalian homolog of yeast Sir2, is an NAD+-dependent deacetylase with relevant functions in cancer, aging, and metabolism among other processes. SIRT1 has a diffuse nuclear localization but is...

    M Campagna, D Herranz, M A Garcia, L Marcos-Villar… in Cell Death & Differentiation (2011)

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