1,760 Result(s)

Article

FADD regulates adipose inflammation, adipogenesis, and adipocyte survival

Adipose tissue, aside from adipocytes, comprises various abundant immune cells. The accumulation of low-grade chronic inflammation in adipose tissue serves as a primary cause and hallmark of insulin resistance...

Jianlei Tang, Yue Ma, Meilin Li, **angpeng Liu, Yuting Wang… in Cell Death Discovery (2024)

Article

Dexmedetomidine and argon in combination against ferroptosis through tackling TXNIP-mediated oxidative stress in DCD porcine livers

Graft availability from donation after circulatory death (DCD) is significantly limited by ischaemia reperfusion (IR) injury. Effective strategies to mitigate IR injury in DCD grafts are essential to improve g...

Qian Chen, Jiashi Sun, **angfeng Liu, Zhigang Qin, Jieyu Li… in Cell Death Discovery (2024)

Article

YTH domain family protein 3 accelerates non-small cell lung cancer immune evasion through targeting CD8⁺ T lymphocytes

Immune evasion is one of the critical hallmarks of malignant tumors, especially non-small cell lung cancer (NSCLC). Emerging findings have illustrated the roles of N⁶-methyladenosine (m⁶A) on NSCLC immune evasion...

Yisheng Luo, Chao Zeng, Zezhong Ouyang, Wenbin Zhu, Jiazhi Wang… in Cell Death Discovery (2024)

Article

Publisher Correction: Restrained Mitf-associated autophagy by Mulberroside A ameliorates osteoclastogenesis and counteracts OVX-Induced osteoporosis in mice

Hong Xue, Zhenhua Feng, Putao Yuan, Li Qiao, Qiliang Lou… in Cell Death Discovery (2024)

Article

Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice

Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive. Protein kinase C-delta (PKC-δ) plays critical roles in the co...

Dongyun Wang, Yue Li, Guiying Li, Mengyu Liu, Zihui Zhou, Ming Wu… in Cell Death Discovery (2024)

Article

Publisher Correction: LINC317.5 as a novel biomarker for hypertriglyceridemia in abnormal glucose metabolism

Yixue Yang, Mengzi Sun, Shoumeng Yan, Nan Yao, **aotong Li… in Cell Death Discovery (2024)

Article

Crosstalk between CAFs and tumour cells in head and neck cancer

Head and neck squamous cell carcinomas (HNSCCs) are amongst the most aggressive, complex, and heterogeneous malignancies. The standard of care treatments for HNC patients include surgery, radiotherapy, chemoth...

**nyang Li, Celia González-Maroto, Mahvash Tavassoli in Cell Death Discovery (2024)

Article

LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism

LIMA1 is a LIM domain and Actin binding 1 protein that acts as a skeleton protein to promote cholesterol absorption, which makes it an ideal target for interfering with lipid metabolism. However, the detailed ...

Zhan Liu, Kexin Fan, Aikedaimu Abudukeremu, Min Gao, **nyue Tan… in Cell Death Discovery (2024)

Article

USP14 deficiency inhibits neointima formation following vascular injury via degradation of Skp2 protein

Ubiquitin-proteasome system (UPS) is involved in vascular smooth muscle cell (VSMC) proliferation. Deubiquitinating enzymes (DUBs) have an essential role in the UPS-regulated stability of the substrate; howeve...

**aohong **a, **aolin Liu, Qiong Xu, Jielei Gu, Sisi Ling… in Cell Death Discovery (2024)

Article

The roles of Th cells in myocardial infarction

Myocardial infarction, commonly known as a heart attack, is a serious condition caused by the abrupt stoppage of blood flow to a part of the heart, leading to tissue damage. A significant aspect of this condit...

Jun Liu, Feila Liu, Tingting Liang, Yue Zhou, **aohan Su, Xue Li… in Cell Death Discovery (2024)

Article

Lactylation of NAT10 promotes N⁴‐acetylcytidine modification on tRNA^Ser-CGA-1-1 to boost oncogenic DNA virus KSHV reactivation

N⁴-acetylcytidine (ac⁴C), a conserved but recently rediscovered RNA modification on tRNAs, rRNAs and mRNAs, is catalyzed by N-acetyltransferase 10 (NAT10). Lysine acylation is a ubiquitous protein modification th...

Qin Yan, **g Zhou, Yang Gu, Wen**g Huang, Mingpeng Ruan… in Cell Death & Differentiation (2024)

Article

Regulation of primary cilia disassembly through HUWE1-mediated TTBK2 degradation plays a crucial role in cerebellar development and medulloblastoma growth

Development of the cerebellum requires precise regulation of granule neuron progenitor (GNP) proliferation. Although it is known that primary cilia are necessary to support GNP proliferation, the exact molecul...

I-Hsuan Lin, Yue-Ru Li, Chia-Hsiang Chang, Yu-Wen Cheng… in Cell Death & Differentiation (2024)

Article

DUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling

DUSP22, an atypical dual-specificity phosphatase enzyme, plays a significant role in regulating multiple kinase signaling pathways by dephosphorylation. Our study demonstrated that decreased DUSP22 expression ...

Hsiao-Han Lin, Cheng-Wei Chang, Yu-Ting Liao, Shauh-Der Yeh… in Cell Death Discovery (2024)