480 Result(s)

Article

Crystal structure of cytotoxin protein suilysin from Streptococcus suis

Cholesterol-dependent cytolysins (CDC) are pore forming toxins. A prototype of the CDC family members is perfringolysin O (PFO), which directly binds to the cell membrane enriched in cholesterol, causing cell ...

Lingfeng Xu, Bo Huang, Huamao Du, Xuejun C. Zhang, Jianguo Xu, Xuemei Li… in Protein & Cell (2010)

Article

Molecular and cellular bases of chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a myeloproliferative disease characterized by the overproduction of granulocytes, which leads to high white blood cell counts and splenomegaly in patients. Based on clinical s...

Yaoyu Chen, Cong Peng, Dongguang Li, Shaoguang Li in Protein & Cell (2010)

Article

New nsp8 isoform suggests mechanism for tuning viral RNA synthesis

During severe acute respiratory syndrome coronavirus (SARS-CoV) infection, the activity of the replication/transcription complexes (RTC) quickly peaks at 6 hours post infection (h.p.i) and then diminishes sign...

Shuang Li, Qi Zhao, Yinjie Zhang, Yang Zhang, Mark Bartlam, Xuemei Li… in Protein & Cell (2010)

Article

Engineering cyanobacteria for fuels and chemicals production

The world’s energy and global warming crises call for sustainable, renewable, carbon-neutral alternatives to replace fossil fuel resources. Currently, most biofuels are produced from agricultural crops and res...

Jie Zhou, Yin Li in Protein & Cell (2010)

Article

DNA replication licensing control and rereplication prevention

Eukaryotic DNA replication is tightly restricted to only once per cell cycle in order to maintain genome stability. Cells use multiple mechanisms to control the assembly of the prereplication complex (pre-RC),...

Chonghua Li, Jian** ** in Protein & Cell (2010)

Article

Cellular models for disease exploring and drug screening

The biopharmaceutical industry has been greatly promoted by the application of drug and disease models, including both animal and cellular models. In particular, the emergence of induced pluripotent stem cells...

Zhi-kun Li, Qi Zhou in Protein & Cell (2010)

Article

Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its αNAC subunit

Nascent polypeptide associated complex (NAC) and its two isolated subunits, αNAC and βNAC, play important roles in nascent peptide targeting. We determined a 1.9 Å resolution crystal structure of the interacti...

Lanfeng Wang, Wenchi Zhang, Lu Wang, Xuejun C. Zhang, Xuemei Li, Zihe Rao in Protein & Cell (2010)

Article

Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines

Seasonal influenza epidemics and influenza pandemics caused by influenza A virus (IAV) has resulted in millions of deaths in the world. The development of anti-IAV vaccines and therapeutics is urgently needed ...

Shibo Jiang, Runming Li, Lanying Du, Shuwen Liu in Protein & Cell (2010)

Article

Candidate Mycobacterium tuberculosis genes targeted by human microRNAs

WeiRui Guo, Jiong-Tang Li, **ao Pan, Li** Wei, Jane Y. Wu in Protein & Cell (2010)

Article

Crystal structure of a novel non-Pfam protein PF2046 solved using low resolution B-factor sharpening and multi-crystal averaging methods

Sometimes crystals cannot diffract X-rays beyond 3.0 Å resolution due to the intrinsic flexibility associated with the protein. Low resolution diffraction data not only pose a challenge to structure determinat...

**g Su, Yang Li, Neil Shaw, Weihong Zhou, Min Zhang, Hao Xu… in Protein & Cell (2010)

Article

Drosophila RecQ5 is required for efficient SSA repair and suppression of LOH in vivo

RecQ5 in mammalian cells has been suggested to suppress inappropriate homologous recombination. However, the specific pathway(s) in which it is involved and the underlining mechanism(s) remain poorly understoo...

Yixu Chen, Wen Dui, Zhongsheng Yu, Changqing Li, Jun Ma, Renjie Jiao in Protein & Cell (2010)

Article

Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus

Influenza virus is the causative agent of the seasonal and occasional pandemic flu. The current H1N1 influenza pandemic, announced by the WHO in June 2009, is highly contagious and responsible for global econo...

Wei Zhang, Jianxun Qi, Yi Shi, Qing Li, Feng Gao, Ye** Sun, **shan Lu… in Protein & Cell (2010)

Article

Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China

Enterovirus 71 (EV71), one of the major causative agents for hand-foot-and-mouth disease (HFMD), has caused more than 100 deaths among Chinese children since March 2008. The EV71 genome encodes an RNAdependent...

Yang Wu, Zhiyong Lou, Yi Miao, Yue Yu, Hui Dong, Wei Peng, Mark Bartlam… in Protein & Cell (2010)

Article

The next-generation sequencing technology and application

As one of the key technologies in biomedical research, DNA sequencing has not only improved its productivity with an exponential growth rate but also been applied to new areas of application over the past few ...

**aoguang Zhou, Lufeng Ren, Qingshu Meng, Yuntao Li, Yude Yu, Jun Yu in Protein & Cell (2010)

Article

Bing Zhi: pioneer of modern biology in China

Ming Li, Le Kang in Protein & Cell (2010)

Article

Structures of the N- and C-terminal domains of MHV-A59 nucleocapsid protein corroborate a conserved RNA-protein binding mechanism in coronavirus

Coronaviruses are the causative agent of respiratory and enteric diseases in animals and humans. One example is SARS, which caused a worldwide health threat in 2003. In coronaviruses, the structural protein N ...

Yanlin Ma, **aohang Tong, **aoling Xu, Xuemei Li, Zhiyong Lou, Zihe Rao in Protein & Cell (2010)

Article

Tumor microenvironment: bidirectional interactions between cancer cells and normal cells

Lu-Yuan Li in Protein & Cell (2010)

Article

Human gut microbiome: the second genome of human body

The human body is actually a super-organism that is composed of 10 times more microbial cells than our body cells. Metagenomic study of the human microbiome has demonstrated that there are 3.3 million unique g...

Baoli Zhu, **n Wang, Lanjuan Li in Protein & Cell (2010)

Article

Crystal structure of a secreted lipase from Gibberella zeae reveals a novel “double-lock” mechanism

Fusarium graminearum (sexual stage: Gibberella zeae) is the causative agent of Fusarium Head Blight (FHB), which is one of the most destructive plant disease of cereals, accounting for high grain yield losses, es...

Zhiyong Lou, Ming Li, Yuna Sun, Ye Liu, Zheng Liu, Wen** Wu, Zihe Rao in Protein & Cell (2010)

Article

Cilia in cell signaling and human disorders

One of the most widespread cellular organelles in nature is cilium, which is found in many unicellular and multicellular organisms. Formerly thought to be a mostly vestigial organelle, the cilium has been disc...

Neil A. Duldulao, Jade Li, Zhaoxia Sun in Protein & Cell (2010)