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    Article

    Tyrosine phosphorylation controls PCNA function through protein stability

    The proliferating cell nuclear antigen (PCNA) is an essential protein for DNA replication and damage repair. How its function is controlled remains an important question. Here, we show that the chromatin-bound...

    Shao-Chun Wang, Yusuke Nakajima, Yung-Luen Yu, Weiya **a… in Nature Cell Biology (2006)

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    Article

    ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

    The RAS–ERK pathway is known to play a pivotal role in differentiation, proliferation and tumour progression. Here, we show that Erk downregulates Forkhead box O 3a (FOXO3a) by directly interacting with and ph...

    Jer-Yen Yang, Cong S. Zong, Weiya **a, Hirohito Yamaguchi… in Nature Cell Biology (2008)

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    Article

    CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells

    The Polycomb group protein EZH2 promotes trimethylation of histone H3K27 and gene silencing. Cdk1 is found to phosphorylate EZH2 to inhibit its methyltransferase activity, affecting EZH2-target genes involved ...

    Yongkun Wei, Ya-Huey Chen, Long-Yuan Li, **gyu Lang, Su-Peng Yeh… in Nature Cell Biology (2011)

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    Article

    Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation

    The argine methyltransferase PRMT5 methylates EGFR. This modification increases EGFR trans-autophosphorylation and attenuates ERK pathway activation.

    Jung-Mao Hsu, Chun-Te Chen, Chao-Kai Chou, Hsu-** Kuo… in Nature Cell Biology (2011)