-
Article
Open AccessImpaired cerebral microvascular endothelial cells integrity due to elevated dopamine in myasthenic model
Myasthenia gravis is an autoimmune disease characterized by pathogenic antibodies that target structures of the neuromuscular junction. However, some patients also experience autonomic dysfunction, anxiety, de...
-
Article
Open AccessLong non-coding RNA LncKdm2b regulates cortical neuronal differentiation by cis-activating Kdm2b
The mechanisms underlying spatial and temporal control of cortical neurogenesis of the brain are largely elusive. Long non-coding RNAs (lncRNAs) have emerged as essential cell fate regulators. Here we found LncKd...
-
Article
Open AccessExcess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia
High salt diet (HSD) is one of the most important risk factors that contribute to many vascular diseases including ischemic stroke. One proposed mechanism underlying the disruption of blood-brain barrier (BBB)...
-
Article
Open AccessAccumulation of natural killer cells in ischemic brain tissues and the chemotactic effect of IP-10
Stroke is accompanied by a distinguished inflammatory reaction that is initiated by the infiltration of immunocytes, expression of cytokines, and other inflammatory mediators. As natural killer cells (NK cells...
