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  1. Article

    Open Access

    circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p

    Esophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor worldwide. Circular RNA (circRNA) is of great value in tumorigenesis progression. However, the mechanism of circFNDC3B in ESCC remains t...

    Dan Song, Ziqi Ye, Fangyu Chen, Liangliang Zhan, **nchen Sun in BMC Cancer (2023)

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  2. Article

    Open Access

    Recombinant human endostatin enhances the radioresponse in esophageal squamous cell carcinoma by normalizing tumor vasculature and reducing hypoxia

    The aim of this study was to investigate the effect of recombinant human endostatin (rh-Endo) in combination with radiation therapy (RT) on esophageal squamous cell carcinoma (ESCC) and explore the potential m...

    Hongcheng Zhu, ** Yang, Yuqiong Ding, Jia Liu, **g Lu… in Scientific Reports (2015)

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  3. No Access

    Article

    Eukaryotic elongation factor 2 kinase confers tolerance to stress conditions in cancer cells

    Eukaryotic elongation factor 2 (eEF2) is a member of the GTP-binding translation elongation factor family that is essential for protein synthesis. eEF2 kinase (eEF2K) is a structurally and functionally unique ...

    Hongcheng Zhu, ** Yang, Jia Liu, Lu Zhou, Chi Zhang… in Cell Stress and Chaperones (2015)

  4. No Access

    Article

    Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α

    Hypoxia is a widespread phenomenon present in many human solid tumors and is associated with a poor prognosis and therapy resistance. Here, we tested the feasibility of melittin, a major component of bee venom...

    ** Yang, Hongcheng Zhu, Yangyang Ge, Jia Liu, **g Cai, Qin Qin… in Tumor Biology (2014)

  5. No Access

    Article

    STAT3 inhibitor NSC74859 radiosensitizes esophageal cancer via the downregulation of HIF-1α

    Radiotherapy is the main therapy for inoperable and locally advanced esophageal squamous cell carcinoma (ESCC). However, radioresistance in ESCC remains a challenge. The aim of this study is to investigate the...

    Chi Zhang, ** Yang, Qu Zhang, Qing Guo, Jia He, Qin Qin, Hongcheng Zhu… in Tumor Biology (2014)

  6. No Access

    Article

    Melittin radiosensitizes esophageal squamous cell carcinoma with induction of apoptosis in vitro and in vivo

    Currently, unresectable esophageal squamous cell carcinoma (ESCC) is primarily treated by chemoradiotherapy. However, the outcome has not improved significantly because of radioresistance of cancer cells. This...

    Hongcheng Zhu, ** Yang, Jia Liu, Yangyang Ge, Qin Qin, **g Lu… in Tumor Biology (2014)

  7. Article

    Open Access

    Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G2 checkpoint and suppression of homologous recombination repair

    Survivin is overexpressed in cancer cells and plays a crucial role in apoptosis evasion. YM155, a small-molecule inhibitor of survivin, could enhance the cytotoxicity of various DNA-damaging agents. Here, we e...

    Qin Qin, Hongyan Cheng, **g Lu, Liangliang Zhan… in Journal of Hematology & Oncology (2014)

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  8. No Access

    Article

    MicroRNA-21 is a novel promising target in cancer radiation therapy

    MicroRNAs (miRNAs) represent an important nonprotein part of the human genome in tumor biology. Among the several types of miRNAs, microRNA-21 (miR-21) is dysregulated in several types of cancer and plays a ke...

    Jia Liu, Hongcheng Zhu, ** Yang, Yangyang Ge, Chi Zhang, Qin Qin, **g Lu… in Tumor Biology (2014)

  9. No Access

    Article

    Smac mimetic compound LCL161 sensitizes esophageal carcinoma cells to radiotherapy by inhibiting the expression of inhibitor of apoptosis protein

    Currently, unresectable esophageal squamous cell carcinoma (ESCC) is primarily treated by chemoradiotherapy. However, the outcome has not improved significantly due to radioresistance of cancer cells. This stu...

    Qin Qin, Yun Zuo, ** Yang, **g Lu, Liangliang Zhan, Li** Xu, Chi Zhang… in Tumor Biology (2014)

  10. No Access

    Article

    Association between survivin -31G>C polymorphism and cancer risk: meta-analysis of 29 studies

    A growing body of evidence has shown the possible relevance of survivin -31G>C (rs9904341) promoter polymorphism to the genetic susceptibility of cancer. Because of the lack of available conclusive data, we perfo...

    Qin Qin, Chi Zhang, Hongcheng Zhu, … in Journal of Cancer Research and Clinical On… (2014)