76 Result(s)

Article

Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

Early insulin therapy is capable to achieve glycemic control and restore β-cell function in newly diagnosed type 2 diabetes (T2D), but its effect on cardiovascular outcomes in these patients remains unclear. I...

Sihui Luo, Xueying Zheng, Wei Bao, Sheng Nie… in Signal Transduction and Targeted Therapy (2024)

Article

Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study

The safety and efficacy of COVID-19 vaccines in the elderly, a high-risk group for severe COVID-19 infection, have not been fully understood. To clarify these issues, this prospective study followed up 157 eld...

Hong-Hong Liu, Yunbo **e, Bao-Peng Yang… in Signal Transduction and Targeted Therapy (2024)

Article

The gasdermin family: emerging therapeutic targets in diseases

The gasdermin (GSDM) family has garnered significant attention for its pivotal role in immunity and disease as a key player in pyroptosis. This recently characterized class of pore-forming effector proteins is...

Chenglong Zhu, Sheng Xu, Ruoyu Jiang, Yizhi Yu… in Signal Transduction and Targeted Therapy (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses

The Orthopoxvirus genus, especially variola virus (VARV), monkeypox virus (MPXV), remains a significant public health threat worldwide. The development of therapeutic antibodies against orthopoxviruses is largely...

Hang Chi, Suo-Qun Zhao, Ru-Yi Chen… in Signal Transduction and Targeted Therapy (2024)

Article

SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl⁻ concentration

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disrupts the epithelial barrier and triggers airway inflammation. The envelope (E) protein, a core virulence structural component of coron...

Jian-Bang Xu, Wei-Jie Guan, Yi-Lin Zhang… in Signal Transduction and Targeted Therapy (2024)

Article

New clinical trial design in precision medicine: discovery, development and direction

In the era of precision medicine, it has been increasingly recognized that individuals with a certain disease are complex and different from each other. Due to the underestimation of the significant heterogene...

**ao-Peng Duan, Bao-Dong Qin, **ao-Dong Jiao… in Signal Transduction and Targeted Therapy (2024)

Article

Navigating Epstein–Barr virus autoimmunity: role of NK cells and T cells in multiple sclerosis

Chu **e, Cong Sun, Mu-Sheng Zeng in Signal Transduction and Targeted Therapy (2024)

Article

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

The human gastrointestinal tract is populated with a diverse microbial community. The vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology, ...

Jian Sheng Loh, Wen Qi Mak, Li Kar Stella Tan… in Signal Transduction and Targeted Therapy (2024)

Article

Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions

**angpeng Sheng, Fang Zhu, Hong Peng, Fan Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial

Immunity-and-matrix-regulatory cells (IMRCs) derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix, which could be mass-produced with stab...

Liangjiang Huang, Song Zhang, Jun Wu… in Signal Transduction and Targeted Therapy (2023)

Article

Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge

Coronavirus disease 2019 (COVID-19) was first reported three years ago, when a group of individuals were infected with the original SARS-CoV-2 strain, based on which vaccines were developed. Here, we develop s...

Qianyun Liu, Haiyan Zhao, Zhiqiang Li… in Signal Transduction and Targeted Therapy (2023)

Article

High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

Normal high-density lipoprotein (nHDL) can induce angiogenesis in healthy individuals. However, HDL from patients with coronary artery disease undergoes various modifications, becomes dysfunctional (dHDL), and...

Zhi-Wei Mo, Yue-Ming Peng, Yi-**n Zhang, Yan Li… in Signal Transduction and Targeted Therapy (2023)

Article

Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis

T lymphopenia, occurring in the early phase of sepsis in response to systemic inflammation, is commonly associated with morbidity and mortality of septic infections. We have previously shown that a sufficient ...

Sheng-yuan Zhang, Qiu-** Xu, Li-na Shi… in Signal Transduction and Targeted Therapy (2023)

Article

Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development

Qi Xu, Miaomiao **e, **aoxuan Liu, Heng Heng… in Signal Transduction and Targeted Therapy (2023)

Article

Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines

The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts on the public health and the global ec...

Liyan Guo, Sheng Lin, Zimin Chen, Yu Cao… in Signal Transduction and Targeted Therapy (2023)

Article

Stellettin B renders glioblastoma vulnerable to poly (ADP-ribose) polymerase inhibitors via suppressing homology-directed repair

**n Peng, Yingying Wang, Shaolu Zhang… in Signal Transduction and Targeted Therapy (2023)

Article

Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies

Despite the success of targeted therapies in cancer treatment, therapy-induced resistance remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via phenotypic switching driven b...

Zhen-Duo Shi, Kun Pang, Zhuo-Xun Wu, Yang Dong… in Signal Transduction and Targeted Therapy (2023)

Article

PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway

Our previous studies have showed that C-C motif chemokine ligand 20 (CCL20) advanced tumor progression and enhanced the chemoresistance of cancer cells by positively regulating breast cancer stem cell (BCSC) s...

Rui Zhang, Mengxue Dong, Juchuanli Tu… in Signal Transduction and Targeted Therapy (2023)

Article

From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism

Alternative splicing (AS) is an important approach for pathogens and hosts to remodel transcriptome. However, tuberculosis (TB)-related AS has not been sufficiently explored. Here we presented the first landsc...

Mengyuan Lyu, Jian Zhou, Yanbing Zhou… in Signal Transduction and Targeted Therapy (2023)