111 Result(s)
-
Article
Open AccessHistone serotonylation in dorsal raphe nucleus contributes to stress- and antidepressant-mediated gene expression and behavior
Mood disorders are an enigmatic class of debilitating illnesses that affect millions of individuals worldwide. While chronic stress clearly increases incidence levels of mood disorders, including major depress...
-
Article
Open AccessPublisher Correction: NDUFS4 regulates cristae remodeling in diabetic kidney disease
-
Article
Open AccessExtend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project
Accurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling performance of bioinformatics pipelines. A reference samp...
-
Article
Open AccessExemestane plus everolimus and palbociclib in metastatic breast cancer: clinical response and genomic/transcriptomic determinants of resistance in a phase I/II trial
The landscape of cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) resistance is still being elucidated and the optimal subsequent therapy to overcome resistance remains uncertain. Here we present the final resu...
-
Article
Open AccessNDUFS4 regulates cristae remodeling in diabetic kidney disease
The mitochondrial electron transport chain (ETC) is a highly adaptive process to meet metabolic demands of the cell, and its dysregulation has been associated with diverse clinical pathologies. However, the ro...
-
Article
Open AccessRegulation of long-range BMP gradients and embryonic polarity by propagation of local calcium-firing activity
Many amniote vertebrate species including humans can form identical twins from a single embryo, but this only occurs rarely. It has been suggested that the primitive-streak-forming embryonic region emits signa...
-
Article
Open AccessGlobal fine-resolution data on springtail abundance and community structure
Springtails (Collembola) inhabit soils from the Arctic to the Antarctic and comprise an estimated ~32% of all terrestrial arthropods on Earth. Here, we present a global, spatially-explicit database on springta...
-
Article
Open AccessFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 thr...
-
Article
Open AccessA fungal plant pathogen discovered in the Devonian Rhynie Chert
Fungi are integral to well-functioning ecosystems, and their broader impact on Earth systems is widely acknowledged. Fossil evidence from the Rhynie Chert (Scotland, UK) shows that Fungi were already diverse in t...
-
Article
Open AccessAdaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer
The recent success of mRNA therapeutics against pathogenic infections has increased interest in their use for other human diseases including cancer. However, the precise delivery of the genetic cargo to cells ...
-
Article
Open AccessAuthor Correction: Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge
-
Article
Open AccessElucidation of the low-expressing erythroid CR1 phenotype by bioinformatic mining of the GATA1-driven blood-group regulome
Genetic determinants underlying most human blood groups are now clarified but variation in expression levels remains largely unexplored. By develo** a bioinformatics pipeline analyzing GATA1/Chromatin immuno...
-
Article
Open AccessGenomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential
There has been limited characterisation of bat-borne coronaviruses in Europe. Here, we screened for coronaviruses in 48 faecal samples from 16 of the 17 bat species breeding in the UK, collected through a bat ...
-
Article
Open AccessA viral pan-end RNA element and host complex define a SARS-CoV-2 regulon
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, generates multiple protein-coding, subgenomic RNAs (sgRNAs) from a longer genomic RNA, all bearing identical termi...
-
Article
Author Correction: The power of genetic diversity in genome-wide association studies of lipids
-
Article
Open AccessGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...
-
Article
Open AccessPublisher Correction: Soil contamination in nearby natural areas mirrors that in urban greenspaces worldwide
-
Article
Open AccessEtiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication
Oncogenic fusions formed through chromosomal rearrangements are hallmarks of childhood cancer that define cancer subtype, predict outcome, persist through treatment, and can be ideal therapeutic targets. Howev...
-
Article
Open AccessGenetic correlations between Alzheimer’s disease and gut microbiome genera
A growing body of evidence suggests that dysbiosis of the human gut microbiota is associated with neurodegenerative diseases like Alzheimer’s disease (AD) via neuroinflammatory processes across the microbiota-...
-
Article
Open AccessSoil contamination in nearby natural areas mirrors that in urban greenspaces worldwide
Soil contamination is one of the main threats to ecosystem health and sustainability. Yet little is known about the extent to which soil contaminants differ between urban greenspaces and natural ecosystems. He...
