7 Result(s)

Article

Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks

Despite the wide effects of cardiorespiratory fitness (CRF) on metabolic, cardiovascular, pulmonary and neurological health, challenges in the feasibility and reproducibility of CRF measurements have impeded i...

Andrew S. Perry, Eric Farber-Eger, Tomas Gonzales, Toshiko Tanaka… in Nature Medicine (2024)

Article

Association between retinal microvascular abnormalities and late-life brain amyloid-β deposition: the ARIC-PET study

Retinal microvascular signs are accessible measures of early alterations in microvascular dysregulation and have been associated with dementia; it is unclear if they are associated with AD (Alzheimer’s disease...

Marco Egle, Jennifer A. Deal, Keenan A. Walker… in Alzheimer's Research & Therapy (2024)

Article

Alzheimer’s and neurodegenerative disease biomarkers in blood predict brain atrophy and cognitive decline

Although blood-based biomarkers have been identified as cost-effective and scalable alternatives to PET and CSF markers of neurodegenerative disease, little is known about how these biomarkers predict future b...

Heather E. Dark, Yang An, Michael R. Duggan… in Alzheimer's Research & Therapy (2024)

Article

Associations between genetically predicted plasma protein levels and Alzheimer’s disease risk: a study using genetic prediction models

Specific peripheral proteins have been implicated to play an important role in the development of Alzheimer’s disease (AD). However, the roles of additional novel protein biomarkers in AD etiology remains elus...

**g**g Zhu, Shuai Liu, Keenan A. Walker, Hua Zhong… in Alzheimer's Research & Therapy (2024)

Article

The role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap

Peripheral inflammation, defined as inflammation that occurs outside the central nervous system, is an age-related phenomenon that has been identified as a risk factor for Alzheimer’s disease. While the role o...

Keenan A. Walker, Lydia M. Le Page, Niccolò Terrando… in Molecular Neurodegeneration (2023)

Article

Correction to: Plasma proteins related to inflammatory diet predict future cognitive impairment

Michael R. Duggan, Lauren Butler, Zhongsheng Peng, Gulzar N. Daya… in Molecular Psychiatry (2023)

Article

Plasma proteins related to inflammatory diet predict future cognitive impairment

Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the develo...

Michael R. Duggan, Lauren Butler, Zhongsheng Peng, Gulzar N. Daya… in Molecular Psychiatry (2023)