11 Result(s)
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Article
Kazuki Takeda
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessImpact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury
This retrospective cohort study established malnutrition’s impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged ≥ 65 years with trau...
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Open AccessCharacteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament
Although the incidence of cervical spinal cord injury (CSCI) with ossification of the posterior longitudinal ligament (OPLL) has increased in older adults, its etiology and neurological outcomes remain unknown...
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Open AccessObservation of hapten-induced sensitization responses for the development of a mouse skin sensitization test, including the elicitation phase
The only official method that can detect the skin sensitizing potential of chemicals, including the elicitation response, is the OECD test guideline (TG) 406. However, this guideline uses guinea pigs, which re...
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Open AccessGenome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese
Adolescent idiopathic scoliosis (AIS) is the most common pediatric spinal deformity. Several AIS susceptibility loci have been identified; however, they could explain only a small proportion of AIS heritabilit...
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Open AccessX-ray structure analysis of bacteriorhodopsin at 1.3 Å resolution
Bacteriorhodopsin (bR) of Halobacterium salinarum is a membrane protein that acts as a light-driven proton pump. bR and its homologues have recently been utilized in optogenetics and other applications. Although ...
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Open AccessA multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis (AIS) is the most common type of spinal deformity and has a significant genetic background. Genome-wide association studies (GWASs) identified several susceptibility loci associ...
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Open AccessAn international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis (AIS) is a common spinal deformity with the prevalence of approximately 3%. We previously conducted a genome-wide association study (GWAS) using a Japanese cohort and identified...
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Article
Open AccessDistribution of valence electrons of the flavin cofactor in NADH-cytochrome b5 reductase
Flavin compounds such as flavin adenine dinucleotide (FAD), flavin mononucleotide and riboflavin make up the active centers in flavoproteins that facilitate various oxidoreductive processes. The fine structura...
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Open AccessStructural studies of the N-terminal fragments of the WW domain: Insights into co-translational folding of a beta-sheet protein
Nascent proteins fold co-translationally because the folding speed and folding pathways are limited by the rate of ribosome biosynthesis in the living cell. In addition, though full-length proteins can fold al...
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Article
Charge-density analysis of an iron–sulfur protein at an ultra-high resolution of 0.48 Å
The ultra-high-resolution structure of the high-potential iron–sulfur protein at 0.48 Å, the highest-resolution X-ray crystal structure of a protein reported so far.
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Structure of the LH1–RC complex from Thermochromatium tepidum at 3.0 Å
The light-harvesting core antenna (LH1) and the reaction centre (RC) of purple photosynthetic bacteria form a supramolecular complex (LH1–RC) to use sunlight energy in a highly efficient manner. Here we report...
