-
Article
Open AccessPhylloquinone improves endothelial function, inhibits cellular senescence, and vascular inflammation
Phylloquinon (PK) and menaquinones (MK) are both naturally occurring compounds belonging to vitamin K group. Present study aimed to comprehensively analyze the influence of PK in several models of vascular dys...
-
Article
Open AccessAccelerated ageing and coronary microvascular dysfunction in chronic heart failure in Tgαq*44 mice
Age represents a major risk factor in heart failure (HF). However, the mechanisms linking ageing and HF are not clear. We aimed to identify the functional, morphological and transcriptomic changes that could b...
-
Article
Open AccessA preliminary metabolites identification of a novel compound with β-adrenolytic activity
The identification of main metabolites and assessment of renal excretion of a novel compound with β-adrenolytic activity (2RS)-1-(1H-indol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol, briefly called ...
-
Article
Open AccessAlterations in arginine and energy metabolism, structural and signalling lipids in metastatic breast cancer in mice detected in plasma by targeted metabolomics and lipidomics
The early detection of metastasis based on biomarkers in plasma may improve cancer prognosis and guide treatment. The aim of this work was to characterize alterations in metabolites of the arginine pathway, en...
