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Article
Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran
In predictions about hepatic clearance (CLH), a number of studies explored the role of albumin and transporters in drug uptake by liver cells, challenging the traditional free-drug theory. It was proposed that li...
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Article
Open AccessA preliminary metabolites identification of a novel compound with β-adrenolytic activity
The identification of main metabolites and assessment of renal excretion of a novel compound with β-adrenolytic activity (2RS)-1-(1H-indol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol, briefly called ...
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Article
Differential effects of liver steatosis on pharmacokinetic profile of two closely related hepatoselective NO-donors; V-PYRRO/NO and V-PROLI/NO
To analyze the effect of liver steatosis and obesity on pharmacokinetic profile of two structurally-related liver-selective NO-donors — V-PYRRO/NO and V-PROLI/NO.
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Article
Towards a comprehensive endothelial biomarkers profiling and endothelium-guided pharmacotherapy
Endothelial dysfunction has prognostic, diagnostic and therapeutic significance in cardiovascular disease, but the endothelial phenotype is still not measured routinely to stratify the cardiovascular risk and ...