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  1. Article

    Open Access

    Real-world study of afatinib in first-line or re-challenge settings for patients with EGFR mutant non-small cell lung cancer

    Afatinib, a second-generation epidermal growth factor receptor (EGFR)—tyrosine kinase inhibitor (TKI) for mutant non-small cell lung cancer (NSCLC), was approved in Japan in 2014. This study evaluated clinical...

    Hisashi Tanaka, Kageaki Taima, Masamichi Itoga, Yoshiko Ishioka… in Medical Oncology (2019)

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  2. Article

    Open Access

    A phase I study of afatinib for patients aged 75 or older with advanced non-small cell lung cancer harboring EGFR mutations

    This phase I trial was conducted to determine the maximum tolerated dose (MTD) and recommended dose of afatinib for phase II trial in elderly patients with advanced non-small cell lung cancer (NSCLC) harboring...

    Hisashi Tanaka, Kageaki Taima, Yoshihito Tanaka, Masamichi Itoga… in Medical Oncology (2018)

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  3. No Access

    Article

    Polyinosinic-Polycytidylic Acid Induces the Expression of GRO-α in BEAS-2B Cells

    Growth-related oncogene protein-α (GRO-α)/CXCLl is a chemokine that activates neutrophils and plays an important role in inflammatory reactions. Polyinosinic-polycytidylic acid (poly IC) is a synthetic double-...

    Koji Yamashita, Tadaatsu Imaizumi, Kageaki Taima, Takashi Fujita… in Inflammation (2005)

  4. No Access

    Article

    Effect of Double-Stranded RNA on the Expression of Epithelial Neutrophil Activating Peptide-78/CXCL-5 in Human Endothelial Cells

    Epithelial neutophil activating peptide-78 (ENA-78)/CXCL-5 is a member of CXC chemokines. ENA-78 was originally described as a factor produced by epithelial cells only. But other types of cells including vascu...

    Tadaatsu Imaizumi, Masaharu Hatakeyama, Kageaki Taima, Akira Ishikawa… in Inflammation (2004)