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Article
Surgical metabolism
Trauma, operative interventions, infection and other disturbances of homeostasis lead to a uniform reaction of the body, namely release and activation of hormones and cytokines. Profound alterations of substr...
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Article
Lower gastrointestinal bleeding: therapeutic strategies, surgical techniques and results
Lower gastrointestinal bleeding (LGIB) is normally treated conservatively or by noninvasive techniques. Emergency operations are only necessary when patients with severe hemorrhage cannot be stabilized by eme...
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Article
Depressed T cell-derived IFN-γ following trauma-hemorrhage: a potential mechanism for diminished APC responses
Prolonged immunosuppression has been demonstrated after trauma-hemorrhage resulting in an increased susceptibility to sepsis. The contribution of antigen-presenting cells (APC) vs T cells to this diminished im...
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Article
Angiogenesis in cancer: molecular mechanisms, clinical impact
Angiogenesis, the formation of new blood vessels from the endothelium of the existing vasculature, is fundamental in tumor growth, progression, and metastasis. Inhibiting tumor angiogenesis is a promising stra...
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Article
Influence of surgical trauma on the mRNA expression of sex hormone receptors in PBMCs in male and female patients
Gender-specific immune responses have been found after trauma-hemorrhage. Male and female sex hormones seem to be responsible for this gender dimorphism. Alterations in sex hormone receptor expression in mice ...
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Article
Long-term outcome after multivisceral and tumor/vascular resection in patients with soft tissue sarcoma
Soft tissue sarcomas (STS) are rare tumors. General treatment is difficult while multimodality treatment strategies are more and more common. In these strategies, surgical resection of the primary tumor is ess...
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Article
Targeting the vasculature of visceral tumors: novel insights and treatment perspectives
Angiogenesis, the formation of new blood vessels from the endothelium of the existing vasculature, describes a crucial process in tumor growth, disease progression, and metastasis. Therefore, the upcoming stra...
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Article
Passion and commensurability: both are needed for a concurrence of surgery and research