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Article
Clinicopathologic analysis of pineal parenchymal tumors of intermediate differentiation: a multi-institutional cohort study by the Kyushu Neuro-Oncology Study Group
Pineal parenchymal tumors of intermediate differentiation (PPTIDs), which were recognized in the 2007 World Health Organization (WHO) classification, are rare, accounting for less than 1% of all central nervou...
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Article
Elimination of the check-valve mechanism of the sacral Tarlov cyst using a rotation flap technique in a pediatric patient: technical note
Symptomatic Tarlov cysts in children are not sufficiently reported and treatment methods for Tarlov cysts are still controversial. The goal of this manuscript is to introduce a new variation of the surgical te...
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Article
A case of pediatric moyamoya disease with severe cerebral vasospasm and delayed cerebral infarction following an intraventricular hemorrhage
Reports on patients with moyamoya disease presenting cerebral ischemic complications after the onset of intraventricular hemorrhage (IVH) and/or intracerebral hemorrhage (ICH) are limited. Herein, we report a ...
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Article
Open AccessDiagnosis and clinical course of ocular ischemic syndrome with retinal vascular abnormalities due to unilateral ocular artery and internal carotid artery stenosis in a child with neurofibromatosis type 1: a case report
Neurofibromatosis type 1 (NF1) is a hereditary disease that causes neurofibromas generally, but it has been reported to sometimes be associated with various forms of blood vessel stenosis, occlusion and vascul...
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Article
Primary central nervous system lymphomas associated with chronic inflammation: diagnostic pitfalls of central nervous system lymphomas
In recent years, the features of lymphomas associated with chronic inflammation, referred to as diffuse large B-cell lymphoma (DLBCL) associated with chronic inflammation (DLBCL-CI), have been elucidated. DLBC...
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Article
Association between extracranial internal carotid artery tortuosity and thromboembolic complications during coil embolization of anterior circulation ruptured aneurysms
The most frequent neurological complication during coil embolization of a ruptured cerebral aneurysm is a thromboembolic event. The association between the tortuosity of the internal carotid artery (ICA) and t...
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Article
Stabilization of vulnerable carotid plaques with proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, a novel class of monoclonal antibodies, reduce low-density lipoprotein cholesterol levels and improve outcomes of myocardial infarction and str...
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Article
Open AccessStatus epilepticus induced by treatment with dopamine agonist therapy for giant prolactinoma: a case report
Dopamine agonists are the standard first-line medical therapy for prolactinoma. We report a rare case of giant prolactinoma with a first epileptic seizure due to rapid reduction of the tumor as a complication ...
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Article
Dural arteriovenous fistula manifesting as pontine hemorrhage at the craniocervical junction
Craniocervical junction (CCJ) dural arteriovenous fistula (DAVF) manifesting as intracerebral hemorrhage is extremely rare. We report the first case of CCJ-DAVF manifesting as pontine hemorrhage. A 69-year-old...
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Article
Outcome of microvascular decompression for hemifacial spasm associated with the vertebral artery
We retrospectively compared the outcome of microvascular decompression (MVD) for hemifacial spasm (HFS) associated with the vertebral artery (VA) with that of MVD for HFS unrelated to the VA. Between April 200...
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Article
Outcome of microvascular decompression for trigeminal neuralgia treated with the stitched sling retraction technique
The purpose of this retrospective study was to describe and evaluate the long-term outcome of microvascular decompression (MVD) with the stitched sling retraction technique for treating trigeminal neuralgia (T...
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Article
Stitched sling retraction technique for microvascular decompression: procedures and techniques based on an anatomical viewpoint
The success of microvascular decompression (MVD) depends on the permanent and complete transposition of the offending vessels. This paper describes the stitched sling retraction techniques for treating trigemi...
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Article
Trans-cerebellomedullary fissure approach with special reference to lateral route
The trans-cerebellomedullary fissure (CMF) approach provides good exposure of the fourth ventricle without splitting the inferior vermis. The popularly utilized trans-CMF approach is performed in the midline s...
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Article
Stratification of medulloblastoma on the basis of histopathological grading
Medulloblastoma (WHO grade IV) is an embryonal tumour of the cerebellum and the most common malignant central nervous system tumour in children. Despite significant advances in treatment, 5-year survival rates...
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Article
Capillary hemangioma of the central nervous system: a comparative study with lobular capillary hemangioma of the skin
Capillary hemangiomas have rarely been reported to develop in the brain or spinal cord. Here we report the histological and immunohistochemical features of ten cases of central nervous system capillary hemangi...
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Article
AXIN1 mutations but not deletions in cerebellar medulloblastomas
Medulloblastoma is a malignant, invasive embryonal tumour of the cerebellum which manifests preferentially in children. A subset of cases is associated with colon cancer and APC germline mutations (Turcot syndrom...
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Article
Germline SDHD mutation in paraganglioma of the spinal cord
Hereditary paraganglioma of the head and neck is associated with germline mutations in the SDHD gene, which encodes a mitochondrial respiratory chain protein. Paragangliomas of the central nervous system are very...
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Article
Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas
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Article
Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas
Glioblastomas, the most malignant human brain tumors, are characterized by marked aneuploidy, suggesting chromosomal instability which may be caused by a defective mitotic spindle checkpoint. We screened 22 g...
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Article
Fas ligand expression and depletion of T-cell infiltration in astrocytic tumors
Fas (APO-1/CD95) ligand (FasL) and its receptor, Fas, play a key role in the regulation of apoptosis in the immune system. FasL acts as a cytotoxic effector molecule to Fas-expressing malignant tumor cells; ho...