46 Result(s)
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Article
Ju Hyun Lee
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Open AccessThe impacts of non-perceptual cognition (NPC) on design process and ideation
Past research theorises that eye-closure and associated mental visualisation, which occurs during the design process, may be important for supporting creativity. Despite these claims, little empirical evidence...
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Open AccessRecent advances in li metal anode protection for high performance lithium-sulfur batteries
Lithium-sulfur batteries (LSBs) have garnered significant attention as a promising next-generation rechargeable battery, offering superior energy density and cost-effectiveness. However, the commercialization ...
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Open AccessImpact of concurrent medications on clinical outcomes of cancer patients treated with immune checkpoint inhibitors: analysis of Health Insurance Review and Assessment data
Medications regulating immune homeostasis and gut microbiota could affect the efficacy of immune checkpoint inhibitors (ICIs). This study aimed to investigate the impact of concurrent medications on the clinic...
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Open AccessCompartmentalized ocular lymphatic system mediates eye–brain immunity
The eye, an anatomical extension of the central nervous system (CNS), exhibits many molecular and cellular parallels to the brain. Emerging research demonstrates that changes in the brain are often reflected i...
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Open AccessLatent Dirichlet Allocation (LDA) topic models for Space Syntax studies on spatial experience
Spatial experience has been extensively researched in various fields, with Space Syntax being one of the most widely used methodologies. Multiple Space Syntax techniques have been developed and used to quantit...
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Nest-relief behaviors and usage of call types in the Kentish plover (Charadrius alexandrinus)
In bi-parental species, breeding pairs cooperate to regulate incubation duration through nest-relief behavior, using vocal signals to communicate when exchanging incubation duties. To better understand this be...
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Open AccessComplexity and Diversity in Palladian Facades
This study presents an analysis of two aesthetic properties, complexity and diversity, in Palladian architecture. The former highlights the fractal dimension of façade geometry, and the latter its semantic random...
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Open AccessMAX: a simple, affordable, and rapid tissue clearing reagent for 3D imaging of wide variety of biological specimens
Transparency of biological specimens is crucial to obtaining detailed 3-dimensional images and understanding the structure and function of biological specimens. This transparency or tissue clearing can be achi...
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Cetuximab resistance induced by hepatocyte growth factor is overcome by MET inhibition in KRAS, NRAS, and BRAF wild-type colorectal cancers
Recent evidence has highlighted the role of hepatocyte growth factor (HGF) as a putative biomarker to predict EGFR inhibitor resistance. This study investigated the impact of plasma HGF levels on EGFR inhibiti...
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Why was he murdered? The first report of the motive for conspecific killing in a flock of captive tree sparrows (Passer montanus) through direct video surveillance
In animal societies, conspecific killing is the most extreme way in which individuals resolve conflicts and is rarely reported in the literature. The reasons for such behavior are unclear because the majority ...
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Open AccessFaulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgeni...
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Examining Visitor-Inhabitant Relations in Palladian Villas
A Justified Plan Graph (JPG) method uses graph mathematics to measure the connectivity properties of an architectural plan, providing insights into how a building may have been used, or how it differs from oth...
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Open AccessCell-line dependency in cerebral organoid induction: cautionary observations in Alzheimer’s disease patient-derived induced pluripotent stem cells
The cerebral organoid (CO) model has been used in the study of various neurodegenerative diseases owing to its physiological implications. However, the CO model may only be representative of certain clinical f...
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Open AccessTuning riboflavin derivatives for photodynamic inactivation of pathogens
The development of effective pathogen reduction strategies is required due to the rise in antibiotic-resistant bacteria and zoonotic viral pandemics. Photodynamic inactivation (PDI) of bacteria and viruses is ...
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Production of human spinal-cord organoids recapitulating neural-tube morphogenesis
Human spinal-cord-like tissues induced from human pluripotent stem cells are typically insufficiently mature and do not mimic the morphological features of neurulation. Here, we report a three-dimensional cult...
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Open AccessModeling axonal regeneration by changing cytoskeletal dynamics in stem cell-derived motor nerve organoids
Oxidative stress triggers axon degeneration and cell death, leading to the development of neurodegenerative diseases. Spinal motor nerves project very long axons, increasing the burden on axonal transport and ...
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Open AccessAmphiregulin can predict treatment resistance to palliative first-line cetuximab plus FOLFIRI chemotherapy in patients with RAS wild-type metastatic colorectal cancer
Amphiregulin (AREG) is an epidermal growth factor receptor (EGFR) ligand. The aim of this study was to investigate the effects of baseline plasma AREG levels in KRAS, NRAS, and BRAF wild-type metastatic colorecta...
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Evaluation of the need for cytoreduction and its potential carcinogenicity in children and young adults with myeloproliferative neoplasms
Myeloproliferative neoplasms are rare at a young age, and few reports have described the disease characteristics and outcomes in this group. This study aimed to elucidate the clinical course of essential throm...
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L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma
L1CAM is a transmembrane protein expressed on neurons that was presumed to be found on neuron-derived extracellular vesicles (NDEVs) in human biofluids. We developed a panel of single-molecule array assays to ...
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Linguistic and cultural perspectives on globalised design education
In an increasingly globalised world, design educators face challenges of complex linguistic and cultural differences in their studios and critique systems. While general issues relating to globalisation and ed...
