3 Result(s)

Article

A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia

Hepcidin plays a central role in iron homeostasis and erythropoiesis. Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin internalization, restore iron efflux from cells, and allow t...

Saroj Vadhan-Raj, Rafat Abonour, Jonathan W. Goldman… in Journal of Hematology & Oncology (2017)

Article

Erratum to: Phase 1 study of oral TAS-102 in patients with refractory metastatic colorectal cancer

Johanna C. Bendell, Lee S. Rosen, Robert J. Mayer… in Cancer Chemotherapy and Pharmacology (2016)

Article

Phase 1 study of oral TAS-102 in patients with refractory metastatic colorectal cancer

To evaluate safety of TAS-102 administered twice daily (bid) on days 1–5 and 8–12 of a 4-week cycle, confirm feasibility of the Japanese recommended dose (RD), 35 mg/m², in Western patients with metastatic colore...

Johanna C. Bendell, Lee S. Rosen, Robert J. Mayer… in Cancer Chemotherapy and Pharmacology (2015)