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  1. No Access

    Article

    Salmonella typhimurium engineered to produce CCL21 inhibit tumor growth

    Intravenously-applied bacteria tend to accumulate in tumors and can sporadically lead to tumor regression. Systemic administration of attenuated Salmonella typhimurium is safe and has shown no significant adverse...

    Markus Loeffler, Gaelle Le’Negrate, Maryla Krajewska… in Cancer Immunology, Immunotherapy (2009)

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    Article

    BMD188, A novel hydroxamic acid compound, demonstrates potent anti-prostate cancer effectsin vitro andin vivo by inducing apoptosis: requirements for mitochondria, reactive oxygen species, and proteases

    A newly synthesized cyclic hydroxamic acid compound, BMD188 [cis-l-hydroxy-4-(l-naphthyl)-6-oc-tylpiperidine-2-one], was found to induce the apoptotic death of cultured prostate cancer cells by activating casp...

    Dean G Tang, Li Li, Zhenyu Zhu, Bindu Joshi… in Pathology & Oncology Research (1998)

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    Article

    Immunochemotherapy of malignant glioma: synergistic activity of CD95 ligand and chemotherapeutics

     Malignant glioma cells are susceptible to CD95(Fas/APO-1)-mediated apoptosis triggered by agonistic antibody. Here we examined the proapoptotic effects of the natural CD95 ligand, a cytotoxic cytokine homolog...

    Wilfried Roth, Adriano Fontana, Martin Trepel… in Cancer Immunology, Immunotherapy (1997)

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    Article

    Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis

     Cytokine-mediated cell death in tumor cells can be achieved through endogenous nitric oxide (NO) from within tumor cells or exogenous NO from either activated macrophages or endothelial cells. The purpose of ...

    Suyun Huang, Yunfang Wang, Pedro J. Beltran… in Cancer Immunology, Immunotherapy (1996)