-
Article
Open AccessTRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs
Deletion of TRAF2 or TRAF3 in B cells prolongs their survival. However, it remains unknown whether deletion of such factors affects B cells’ ability to tolerate DNA damage, which can be induced by chemotherapeuti...
-
Article
Open AccessDifferential responses to immune checkpoint inhibitor dictated by pre-existing differential immune profiles in squamous cell carcinomas caused by same initial oncogenic drivers
While immune checkpoint inhibitors (ICI) were approved for head and neck squamous cell carcinomas (HNSCCs), the response rate remains relatively low. Mechanisms underlying ICI unresponsiveness versus sensitivi...
-
Article
Modulation of synaptic potentials and cell excitability by dendritic KIR and KAs channels in nucleus accumbens medium spiny neurons: A computational study
The nucleus accumbens (NAc), a critical structure of the brain reward circuit, is implicated in normal goal-directed behaviour and learning as well as pathological conditions like schizophrenia and addiction. ...
-
Article
Open AccessKIR currents suppress neuronal spiking for unsynchronized distal synaptic inputs in striatal medium spiny neurons: a computational study
-
Article
Open AccessKIR channels in nucleus accumbens MS neurons modulate integration of excitatory synaptic inputs: a computational study