5 Result(s)

Article

TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs

Deletion of TRAF2 or TRAF3 in B cells prolongs their survival. However, it remains unknown whether deletion of such factors affects B cells’ ability to tolerate DNA damage, which can be induced by chemotherapeuti...

Monika Vashisht, Huaibin Ge, Jessy John, Harlie A. McKelvey… in Cell Death & Disease (2023)

Article

Differential responses to immune checkpoint inhibitor dictated by pre-existing differential immune profiles in squamous cell carcinomas caused by same initial oncogenic drivers

While immune checkpoint inhibitors (ICI) were approved for head and neck squamous cell carcinomas (HNSCCs), the response rate remains relatively low. Mechanisms underlying ICI unresponsiveness versus sensitivi...

Samantha M. Y. Chen, Vince Popolizio… in Journal of Experimental & Clinical Cancer … (2022)

Article

K_IR currents suppress neuronal spiking for unsynchronized distal synaptic inputs in striatal medium spiny neurons: a computational study

Jessy John, Rohit Manchanda in BMC Neuroscience (2010)

Article

K_IR channels in nucleus accumbens MS neurons modulate integration of excitatory synaptic inputs: a computational study

Jessy John, Rohit Manchanda in BMC Neuroscience (2009)