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  1. No Access

    Article

    Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function

    Hypoxia-inducible factor (HIF)-1α is a master regulator of inflammatory activities of myeloid cells, including neutrophils and macrophages. These studies examine the role of myeloid cell HIF-1α in regulating a...

    Laura E. Crotty Alexander, Kathryn Akong-Moore… in Journal of Molecular Medicine (2013)

  2. No Access

    Article

    The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling

    Chronic inflammation of the airways is associated with remodeling and fibrosis, leading to a progressive decline in lung function in people with severe asthma. Michael Croft and his colleagues report that in m...

    Taylor A Doherty, Pejman Soroosh, Naseem Khorram, Satoshi Fukuyama… in Nature Medicine (2011)

  3. Article

    Open Access

    Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13

    In this study we examined the role of Siglec-F, a receptor highly expressed on eosinophils, in contributing to mucus expression, airway remodeling, and Siglec-F ligand expression utilizing Siglec-F deficient m...

    Jae Youn Cho, Dae Jae Song, Alexa Pham, Peter Rosenthal… in Respiratory Research (2010)

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  4. Article

    Open Access

    Chronic allergen challenge induces bronchial mast cell accumulation in BALB/c but not C57BL/6 mice and is independent of IL-9

    As genetically engineered mutant mice deficient in single genes are usually generated on a C57BL/6 background, to study mast cell trafficking in mutant mice, we initially investigated whether mast cells accumu...

    Suzan Pae, Jae Youn Cho, Shanna Dayan, Marina Miller, Alan D. Pemberton… in Immunogenetics (2010)

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  5. No Access

    Article

    Systemic Administration of Immunostimulatory DNA Sequences Mediates Reversible Inhibition of Th2 Responses in a Mouse Model of Asthma

    This study investigated whether immunostimulatory DNA sequences (ISS) induce a transient or sustained inhibition of Th2 responses to inhaled antigen. We sensitized mice with subcutaneous injections to develop ...

    David H. Broide, Greg Stachnick, Diego Castaneda… in Journal of Clinical Immunology (2001)

  6. No Access

    Article

    Modulation of asthmatic response by immunostimulatory DNA sequences

    A variety of DNA-based methods of modulating the immune and/or inflammatory response in animal models of asthma have shown significant promise. Antisense strategies seek to inhibit expression of specific host ...

    David Broide, Jae Youn Cho, Marina Miller… in Springer Seminars in Immunopathology (2000)