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Article
Transpupillary thermotherapy (TTT) by infrared irradiation of choroidal melanoma
We studied the destructive effect of hyperthermia at sub-photocoagulation level of 45–60 °C on melanomas. Optimal conditions for spreading of heat into tissue are a wavelength of 700–900 nm, a temperature of 4...
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Article
Determination of basal tear turnover in insulin-dependent diabetes mellitus patients by fluorophotometry
The tear turnover was determined by fluorophotometry in 25 insulin-dependent diabetes mellitus (IDDM) patients without retinopathy and 29 IDDM patients with (pre-)proliferative retinopathy. The results were co...
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Article
Xenon arch photocoagulator used for transpupillary hyperthermia
The technique of near-infrared irradiation to obtain tumour necrosis in experimental pigmented melanomas is described. The xenon arch photocoagulator was modified and adapted for hyperthermia treatment. The ad...
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Article
Effects of microwave-induced hyperthermia on the anterior segment of healthy rabbit eyes
Hyperthermia was induced in nine healthy rabbit eyes by means of a microwave 2450 MHz stripline applicator. The anterior segment of each eye was heated to a fixed temperature of between 42° C and 46° C for 30 ...
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Article
Blood retinal and blood aqueous barriers in diabetics by fluorophotometry
The permeability of the blood retinal barrier (PBRB) and the diffusion coefficient into the anterior chamber (kd) in 20 insulin dependent (ID) and in 11 non-insulin dependent (NID) diabetics with various degrees ...
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Article
The effect of therapeutic ultrasound on the average of multiple intraocular pressures throughout the day in therapy-resistant glaucoma
The effect of therapeutic ultrasound was evaluated in 17 patients with therapy-resistant glaucoma by comparing average intraocular pressure (IOP) curves measured before and 3–4 months after insonification. The...
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Article
Spontaneous retinal haemorrhages
Five patients are described with spontaneous retinal haemorrhages. In two patients small retinal haemorrhages occurred at the posterior pole, in one of them after physical exertion. In three patients multiple ...
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Article
Early morphological changes induced by photodynamic therapy in amelanotic greene melanoma implanted in the anterior eye chamber of rabbits
Morphological changes induced by photodynamic therapy (PDT) in amelanotic Greene melanoma implanted in the anterior eye chamber of rabbits were followed up to 24 h after PDT to study the development of tissue ...
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Article
Ocular and orbital metastasis of cutaneous melanomas
Two patients with orbital metastasis from cutaneous melanoma are described. In one patient the metastatic tumour was located in the iris, in the other one it was located in the lateral rectus muscle. Only symp...
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Article
Plasma fluorescein decay determination during fluorophotometry
Two useful methods for determination of the decay curve of non-protein bound fluorescein (NPBF) in plasma up to 1 hour after intravenous fluorescein injection are described and evaluated. The course of NPBF is...
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Article
Pigmented paravenous retinochoroidal atrophy (PPRA)
Five patients with paravenous pigmented retinochoroidal atrophy (PPRA) are described. Signs of active uveitis and progression of the fundus lesions were observed in one patient. An inflammatory origin of this ...
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Article
Potential radiopharmaceuticals for the detection of ocular melanoma
The uptake and distribution of several 4-(substituted amino)-iodoquinolines, 131I-labelled, and of 67Ga-citrate were investigated in Syrian golden hamsters with Greene melanomas. Because of its uptake in the mela...
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Article
Enzyme activities in the rabbit cornea during immunogenic keratitis
In rabbits inflammation of the cornea was induced by intrastromal injection of horse serum. Between 2 and 4 weeks after injection, infiltration of the cornea with leukocytes and neovascularization could be obs...
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Article
Association of birdshot retinochoroidopathy and HLA-A29 antigen
We tested the association of birdshot retinochoroidopathy and the HLA-A29 antigen. We could confirm a high association, as found by Nussenblatt et al. in 1982.
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Article
Abstracts of papers pharmacological meeting
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Article
Irrigation with mercury chloride and sodium hypochlorite to prevent local recurrence after excision of conjunctival melanoma An experimental study
Two chemical agents, sodium hypochlorite 0.5% (Dakin's solution) and mercury chloride 0.1%, capable of killing seeded tumour cells, were used for washing the cornea and conjunctiva of rabbits. Both agents prod...
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Article
Conjunctival melanomas in The Netherlands: a follow-up study
In a follow-up study of 45 conjunctival melanoma patients the recurrence rate after local excision was 80% but the mortality rate due to metastasis was low, only 2 out of 25 cases in which the recurrences coul...
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Article
Computer fluorophotometry
The possibilities of a new commercial sensitive fluorophotometer are described. The advantages of the use of a computer for measurement and processing of the registered data are discussed.
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Article
Local metastasis in conjunctival melanoma
After excision of conjunctival melanomas the rate of recidivation is high. This may partly be due to local seeding of tumour cells in the excision wound, as we observed in one patient. We now use a sodiumhypoc...
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Article
Acyclovir treatment in stromal herpetic keratitis
Thirty-five patients with long-standing deep stromal herpes simplex keratitis were treated with 3% acyclovir ointment and corticosteroids. All patients were cured in 2 to 4 weeks, independent of both the durat...