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Article
Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity
Defects in pathways governing genomic fidelity have been linked to improved response to immune checkpoint blockade therapy (ICB). Pathogenic POLE/POLD1 mutations can cause hypermutation, yet how diverse mutations...
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Article
CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by forming local chromatin domains
Insulators play a critical role in spatiotemporal gene regulation in animals. The evolutionarily conserved CCCTC-binding factor (CTCF) is required for insulator function in mammals, but not all of its binding ...
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Article
Molecular markers for Diadegma (Hymenoptera: Ichneumonidae) species distinction and their use to study the effects of companion plants on biocontrol of the diamondback moth
Molecular markers facilitate the quantification of parasitization of pest species and the distinction of related parasitoid species. We designed new markers that allow the distinction of often misidentified Diade...