62 Result(s)
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Article
Isaiah J. Fidler
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Open AccessThe challenge of targeting metastasis
Metastases that are resistant to conventional therapy are the major cause of death from cancer. In most patients, metastasis has already occurred by the time of diagnosis. Thus, the prevention of metastasis is...
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Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis
Although recent studies have shown that adenosine-to-inosine (A-to-I) RNA editing occurs in microRNAs (miRNAs), its effects on tumour growth and metastasis are not well understood. We present evidence of CREB-...
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Finding the tumor copycat: Therapy fails, patients don't
The complexity of human metastatic cancer is difficult to mimic in mouse models. As a consequence, seemingly successful studies in murine models do not translate into success in late phases of clinical trials,...
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The brain microenvironment and cancer metastasis
The process of metastasis consists of a series of sequential, selective steps that few cells can complete. The outcome of cancer metastasis depends on multiple interactions between metastatic cells and homeost...
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Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy
Immunohistochemical analysis of human colon cancers growing in the cecal walls of nude mice revealed that epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor 2 (VEGFR2) were...
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Impact of sentinel lymphadenectomy on survival in a murine model of melanoma
Lymphatic map** and sentinel lymph node biopsy—also termed sentinel lymphadenectomy (SL)—has become a standard of care for patients with primary invasive cutaneous melanoma. This technique has been shown to ...
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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
Researchers have been studying metastasis for more than 100 years, and only recently have we gained insight into the mechanisms by which metastatic cells arise from primary tumours and the reasons that certain...
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Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population
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Evidence for the causal role of endogenous interferon-α/β in the regulation of angiogenesis, tumorigenicity, and metastasis of cutaneous neoplasms
Primary tumor growth and metastasis depend on angiogenesis, which is determined by the balance between proangiogenic and antiangiogenic molecules. Interferon (IFN)-α and -β inhibit angiogenesis through downreg...
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Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells
Stat1 is deficient or inactive in many types of human tumors whereas some tumors have activated Stat1. Whether Stat1 affects tumor growth and metastasis is unclear. In the present study, we used Stat1 knockout...
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Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
Since the NF-κB/relA transcription factor is constitutively activated in human prostate cancer cells, we determined whether blocking NF-κB/relA activity in human prostate cancer cells affected their angiogenes...
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Chemotherapeutic drugs—more really is not better
Recent insights into the molecular mechanisms that regulate the process of metastasis and the complex interactions between metastatic cells and host factors have provided a biological foundation for the design...
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Mekk3 is essential for early embryonic cardiovascular development
The early development of blood vessels consists of two phases, vasculogenesis and angiogenesis, which involve distinct and also overlap** molecular regulators, but the intracellular signal transduction pathw...
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Expression of vascular endothelial growth factor by human renal cancer cells enhances angiogenesis of primary tumors and production of ascites but not metastasis to the lungs in nude mice
We determined the role that vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), plays in the progression of human renal cell cancer in nude mice. Low metastatic and low...
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The Biology of Melanoma Brain Metastasis
Brain metastases are clinically diagnosed in the majority of patients with metastatic melanoma. The prognosis for patients with melanoma brain metastasis is poor with a median survival time of 6 months after d...
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Critical determinants of cancer metastasis: rationale for therapy
The major cause of death from cancer is metastases that are resistant to conventional therapies. Several reasons account for treatment failure in patients with metastases. First, neoplasms are biologically he...
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Orthotopic Models are Necessary to Predict Therapy of Transplantable Tumors in Mice
Rapid evaluation of new cytotoxic agents and biological response modifiers for therapy of cancer and elucidation of their mechanisms of action require the use of relevant animal models. It is well established ...
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Suppression of tumorigenicity and metastasis in murine UV-2237 fibrosarcoma cells by infection with a retroviral vector harboring the interferon-beta gene
In this study, we endeavored to determine the effectiveness of interferon β (IFNβ) gene therapy against highly metastatic murine UV-2237m fibrosarcoma cells. UV-2237m cells were engineered to produce murine I...
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Therapy of cancer metastasis by activation of the inducible nitric oxide synthase
The process of cancer metastasis consists of multiple sequential and highly selective steps. The vast majority of tumor cells that enter the circulation die rapidly; only a few survive to produce metastases. T...
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Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2
Recent studies have shown that the treatment of nonmetastatic K-1735 murine melanoma cells with cytokines induces the production of nitric oxide (NO) and hence cell death. The purpose of this study was to dete...
