27 Result(s)
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Open AccessThe challenge of targeting metastasis
Metastases that are resistant to conventional therapy are the major cause of death from cancer. In most patients, metastasis has already occurred by the time of diagnosis. Thus, the prevention of metastasis is...
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Finding the tumor copycat: Therapy fails, patients don't
The complexity of human metastatic cancer is difficult to mimic in mouse models. As a consequence, seemingly successful studies in murine models do not translate into success in late phases of clinical trials,...
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The brain microenvironment and cancer metastasis
The process of metastasis consists of a series of sequential, selective steps that few cells can complete. The outcome of cancer metastasis depends on multiple interactions between metastatic cells and homeost...
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Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy
Immunohistochemical analysis of human colon cancers growing in the cecal walls of nude mice revealed that epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor 2 (VEGFR2) were...
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Impact of sentinel lymphadenectomy on survival in a murine model of melanoma
Lymphatic map** and sentinel lymph node biopsy—also termed sentinel lymphadenectomy (SL)—has become a standard of care for patients with primary invasive cutaneous melanoma. This technique has been shown to ...
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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
Researchers have been studying metastasis for more than 100 years, and only recently have we gained insight into the mechanisms by which metastatic cells arise from primary tumours and the reasons that certain...
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Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population
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Evidence for the causal role of endogenous interferon-α/β in the regulation of angiogenesis, tumorigenicity, and metastasis of cutaneous neoplasms
Primary tumor growth and metastasis depend on angiogenesis, which is determined by the balance between proangiogenic and antiangiogenic molecules. Interferon (IFN)-α and -β inhibit angiogenesis through downreg...
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Chemotherapeutic drugs—more really is not better
Recent insights into the molecular mechanisms that regulate the process of metastasis and the complex interactions between metastatic cells and host factors have provided a biological foundation for the design...
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Mekk3 is essential for early embryonic cardiovascular development
The early development of blood vessels consists of two phases, vasculogenesis and angiogenesis, which involve distinct and also overlap** molecular regulators, but the intracellular signal transduction pathw...
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Expression of vascular endothelial growth factor by human renal cancer cells enhances angiogenesis of primary tumors and production of ascites but not metastasis to the lungs in nude mice
We determined the role that vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), plays in the progression of human renal cell cancer in nude mice. Low metastatic and low...
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The Biology of Melanoma Brain Metastasis
Brain metastases are clinically diagnosed in the majority of patients with metastatic melanoma. The prognosis for patients with melanoma brain metastasis is poor with a median survival time of 6 months after d...
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Orthotopic Models are Necessary to Predict Therapy of Transplantable Tumors in Mice
Rapid evaluation of new cytotoxic agents and biological response modifiers for therapy of cancer and elucidation of their mechanisms of action require the use of relevant animal models. It is well established ...
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Therapy of cancer metastasis by activation of the inducible nitric oxide synthase
The process of cancer metastasis consists of multiple sequential and highly selective steps. The vast majority of tumor cells that enter the circulation die rapidly; only a few survive to produce metastases. T...
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Modulation of tumor cell response to chemotherapy by the organ environment
The outcome of cancer metastasis depends on the interaction of metastatic cells with various host factors. The implantation of human cancer cells into anatomically correct (orthotopic) sites in nude mice can b...
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Metastasis as a consequence of aberrant homeostasis
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Characterization of the invasive and metastatic phenotype in human renal cell carcinoma
The purpose of these studies was to identify some characteristics of metastatic cells and deficiencies of non-metastatic cells in the heterogeneous SN12 human renal cell carcinoma. The SN12 parental line and s...
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New developments in in vivo models of neoplasia
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Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of metastasis
Human colon carcinomas (HCC) are heterogeneous for a varriety of biological properties that include invasion and metastasis. The presence of a small subpopulation of cells with a highly metastatic phenotype ha...
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Orthotopic implantation is essential for the selection, growth and metastasis of human real cell cancer in nude mice
Human neoplasms are heterogeneous for a variety of biological properties that include invasion and metastasis. The presence of a small subpopulation of cells with a highly metastatic phenotype has important cl...
