12 Result(s)
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Article
Isabel Wurster
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Article
Open AccessThe comorbidity profiles and medication issues of patients with multiple system atrophy: a systematic cross-sectional analysis
Multiple system atrophy (MSA) is a complex and fatal neurodegenerative movement disorder. Understanding the comorbidities and drug therapy is crucial for MSA patients’ safety and management.
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Open AccessLongitudinal cognitive decline characterizes the profile of non-PD-manifest GBA1 mutation carriers
With disease-modifying treatment for Parkinson’s disease (PD) associated with variants in the glucocerebrosidase gene (GBA1) under way, the challenge to design clinical trials with non-PD-manifest GBA mutation ca...
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Open AccessCSF α-synuclein seed amplification kinetic profiles are associated with cognitive decline in Parkinson’s disease
Seed amplification assays have been implemented in Parkinson’s disease to reveal disease-specific misfolded alpha-synuclein aggregates in biospecimens. While the assays’ qualitative dichotomous seeding respons...
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Open AccessInflammatory CSF profiles and longitudinal development of cognitive decline in sporadic and GBA-associated PD
Inflammation modifies the incidence and progression of Parkinson’s disease (PD). By using 30 inflammatory markers in CSF in 498 people with PD and 67 people with dementia with Lewy bodies (DLB) we show that: (...
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Open AccessLinking the phenotype of SNCA Triplication with PET-MRI imaging pattern and alpha-synuclein CSF seeding
Lewy-body pathology with aggregation of abnormal conformations of the protein alpha-synuclein (α-Syn) represent the histopathological hallmarks of Parkinson’s disease (PD). Genetic prototypes such as PD due to...
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Open AccessAssociation between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies
The clinicopathological heterogeneity in Lewy-body diseases (LBD) highlights the need for pathology-driven biomarkers in-vivo. Misfolded alpha-synuclein (α-Syn) is a lead candidate based on its crucial role in di...
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Open AccessProspective longitudinal course of cognition in older subjects with mild parkinsonian signs
Mild parkinsonian signs (MPS) are common in older people and are associated with an increased risk of different neurodegenerative diseases. This study prospectively evaluates the longitudinal course of cogniti...
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Autonomic dysfunction in subjects at high risk for Parkinson’s disease
Aim of this project was to evaluate autonomic dysfunction in subjects proposed to be at high risk to develop Parkinson’s disease (PD) compared to control subjects and PD patients at different disease stages. C...
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Open AccessAssociation between vestibulo-ocular reflex suppression, balance, gait, and fall risk in ageing and neurodegenerative disease: protocol of a one-year prospective follow-up study
Falls frequency increases with age and particularly in neurogeriatric cohorts. The interplay between eye movements and locomotion may contribute substantially to the occurrence of falls, but is hardly investig...
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Clinical characteristics related to worsening of motor function assessed by the Unified Parkinson’s Disease Rating Scale in the elderly population
There is evidence that nigrostriatal pathology may at least partly underlie mild Parkinsonian signs. We evaluated whether an increase in the Unified Parkinson’s Disease Rating Scale part III (UPDRS-III) could ...
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Parkinson’s disease with and without preceding essential tremor-similar phenotypes: a pilot study
The aim of this pilot study was to compare clinical aspects of tremor-dominant Parkinson’s disease (PD) patients with and without preceding essential tremor to identify characteristics of these two subgroups. ...
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Risk factors and prodromal markers and the development of Parkinson’s disease
Identification of risk factors and prodromal markers for Parkinson’s disease (PD) and the understanding of the point in time of first occurrence is essential for the early detection of incident PD. In this thr...
