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Article
Clinical impact of hyperattenuation of adrenal glands on contrast-enhanced computed tomography of polytraumatised patients
To evaluate the prognostic value of hyperattenuating adrenal glands on contrast-enhanced CT of polytraumatised patients.
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Article
PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death
To achieve malignancy, cancer cells convert numerous signaling pathways, with evasion from cell death being a characteristic hallmark. The cell death machinery represents an anti-cancer target demanding consta...
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Open AccessBeyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells
Major contributors to atherosclerosis are oxidative damage and endoplasmic reticulum (ER) stress-induced apoptosis; both of which can be diminished by the anti-oxidative protein paraoxonase-2 (PON2). ER stress...
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Article
Comparison of the cytotoxicity and DNA-damaging properties of 2,4-D and U 46 D Fluid (dimethylammonium salt of 2,4-D)
U 46 D Fluid (the dimethylammonium salt of 2,4-dichlorophenoxyacetic acid in a commercial formulation) was more toxic to human fibroblasts than 2,4-dichlorophenoxyacetic acid (2,4-D). Moreover, U 46 D Fluid in...
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Article
Metabolism of pentachlorophenol to tetrachlorohydroquinone by human liver homogenate
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Correlation of the colony-forming abilities of xeroderma pigmentosum fibroblasts with repair-specific DNA incision reactions catalyzed by cell-free extracts
Several normal and XP group A fibroblast cell lines were exposed to the weakly carcinogenic and toxic agent methyl methanesulfonate, and the differences in their abilities to form colonies were determined. The...
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Article
On the biochemical mechanism of tumorigenesis in mouse skin
Mice were treated on their back skin with a single promoting dose of the tritium labelled phorbol ester A 1 (TPA-20-3H) in the standard manner. Methods were investigated for determination of the fate and distribu...