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  1. Article

    PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death

    To achieve malignancy, cancer cells convert numerous signaling pathways, with evasion from cell death being a characteristic hallmark. The cell death machinery represents an anti-cancer target demanding consta...

    E-M Schweikert, A Devarajan, I Witte, P Wilgenbus, J Amort… in Cell Death & Differentiation (2012)

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  2. Article

    Open Access

    Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells

    Major contributors to atherosclerosis are oxidative damage and endoplasmic reticulum (ER) stress-induced apoptosis; both of which can be diminished by the anti-oxidative protein paraoxonase-2 (PON2). ER stress...

    I Witte, S Altenhöfer, P Wilgenbus, J Amort, A M Clement, A Pautz… in Cell Death & Disease (2011)

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