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PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death
To achieve malignancy, cancer cells convert numerous signaling pathways, with evasion from cell death being a characteristic hallmark. The cell death machinery represents an anti-cancer target demanding consta...
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Article
Open AccessBeyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells
Major contributors to atherosclerosis are oxidative damage and endoplasmic reticulum (ER) stress-induced apoptosis; both of which can be diminished by the anti-oxidative protein paraoxonase-2 (PON2). ER stress...