5 Result(s)
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Article
Huimin Tao
Cell Biology
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Article
Open AccessmTORC1 accelerates osteosarcoma progression via m6A-dependent stabilization of USP7 mRNA
Osteosarcoma (OS) is considered a sex steroid hormone-dependent bone tumor. The development and progression of OS are regulated by 17β-estradiol (E2). However, the detailed mechanisms of E2-modulated OS progre...
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Open AccessEstrogen/ER in anti-tumor immunity regulation to tumor cell and tumor microenvironment
As the essential sexual hormone, estrogen and its receptor has been proved to participate in the regulation of autoimmunity diseases and anti-tumor immunity. The adjustment of tumor immunity is related to the ...
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Open AccesslncRNAs: function and mechanism in cartilage development, degeneration, and regeneration
With the increasing incidence of cartilage-related diseases such as osteoarthritis (OA) and intervertebral disc degeneration (IDD), heavier financial and social burdens need to be faced. Unfortunately, there i...
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Open AccessCheckpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells
AZD7762 is a checkpoint kinase 1 (Chk 1) inhibitor, which has been reported to sensitize many tumor cells to DNA damage. However, whether AZD7762 could sensitize osteosarcoma cells to chemotherapy cisplatin ha...
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Open AccessEscin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells in vitro and in vivo
Osteosarcoma is one of the most malignant neoplasms in adolescents, and it generally develops multidrug resistance. Escin, a natural mixture of triterpene saponins isolated from Aesculus hippocastanum (horse c...
