198 Result(s)
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English
Life Sciences
Hui**g Chen
Article
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Article
Correction: Corrigendum: Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
Nat. Struct. Mol. Biol. 11, 1192–1197 (2004). A typographical error was inadvertently introduced in Figure 1a. The corrected chemical structure is shown below. The authors apologize for any inconvenience this ...
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Open AccessConservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex
Ypt/Rab GTPases and their GEF activators regulate intra-cellular trafficking in all eukaryotic cells. In S. cerivisiae, the modular TRAPP complex acts as a GEF for the Golgi gatekeepers: Ypt1 and the functional p...
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Open AccessDetecting non-coding selective pressure in coding regions
Comparative genomics approaches, where orthologous DNA regions are compared and inter-species conserved regions are identified, have proven extremely powerful for identifying non-coding regulatory regions loca...
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Open AccessGASdb: a large-scale and comparative exploration database of glycosyl hydrolysis systems
The genomes of numerous cellulolytic organisms have been recently sequenced or in the pipeline of being sequenced. Analyses of these genomes as well as the recently sequenced metagenomes in a systematic manner...
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Open AccessIdentification and molecular characterization of a novel flavin-free NADPH preferred azoreductase encoded by azoB in Pigmentiphaga kullae K24
Microbial degradation of azo dyes is commonly initiated by the reduction of the azo bond(s) by a group of NADH or NADPH dependant azoreductases with many requiring flavin as a cofactor. In this study, we repor...
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Open AccessAnalysis of rice RNA-dependent RNA polymerase 1 (OsRDR1) in virus-mediated RNA silencing after particle bombardment
RNA-dependent RNA polymerases (RDRs) play a key role in various RNA silencing pathways in many organisms. Using the nucleotide sequence of SGS2/SDE1/RDR6 in Arabidopsis as the search query for sequences that flan...
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Open AccessA novel anti-virulence gene revealed by proteomic analysis in Shigella flexneri 2a
Shigella flexneri is a gram-negative, facultative pathogen that causes the majority of communicable bacterial dysenteries in develo** countries. The virulence factors of S. flexneri have been shown to be produ...
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Open AccessWhole genome co-expression analysis of soybean cytochrome P450 genes identifies nodulation-specific P450 monooxygenases
Cytochrome P450 monooxygenases (P450s) catalyze oxidation of various substrates using oxygen and NAD(P)H. Plant P450s are involved in the biosynthesis of primary and secondary metabolites performing diverse bi...
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Poly(C)-binding protein 1 (PCBP1) mediates housekee** degradation of mitochondrial antiviral signaling (MAVS)
Mitochondrial antiviral signaling (MAVS) is a key adaptor in cellular antiviral innate immunity. We previously identified poly(C)-binding protein 2 (PCBP2) as a feedback inhibitor of MAVS that facilitates its ...
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CFTR mediates bicarbonate-dependent activation of miR-125b in preimplantation embryo development
Although HCO3− is known to be required for early embryo development, its exact role remains elusive. Here we report that HCO3− acts as an environmental cue in regulating miR-125b expression through CFTR-mediated ...
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Open AccessDetection of genetic association and functional polymorphisms of UGDH affecting milk production trait in Chinese Holstein cattle
We previously localized a quantitative trait locus (QTL) on bovine chromosome 6 affecting milk production traits to a 1.5-Mb region between BMS483 and MNB-209 via genome scanning followed by fine map**.
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The essential adaptors of innate immune signaling
Microbial components and the endogenous molecules released from damaged cells can stimulate germ-line-encoded pattern recognition receptors (PRRs) to transduce signals to the hub of the innate immune signaling...
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Open AccessA systems-based approach to analyse the host response in murine lung macrophages challenged with respiratory syncytial virus
Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in young children. The degree of disease severity is determined by the host response to infection. Lung macrophages ...
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Open AccessGenome analysis and signature discovery for diving and sensory properties of the endangered Chinese alligator
Crocodilians are diving reptiles that can hold their breath under water for long periods of time and are crepuscular animals with excellent sensory abilities. They comprise a sister lineage of birds and have n...
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Open AccessComparison of the osmoregulatory capabilities among three amphibious sea snakes (Laticauda spp.) in Taiwan
The three species of amphibious sea snakes (Laticauda semifasciata, L. laticaudata, and L. colubrina) in Taiwan were described as having different habitat affinities from terrestrial to marine. In this study, the...
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Open AccessSpatial-temporal targeting of lung-specific mesenchyme by a Tbx4enhancer
Reciprocal interactions between lung mesenchymal and epithelial cells play essential roles in lung organogenesis and homeostasis. Although the molecular markers and related animal models that target lung epith...
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Open AccessTransmembrane routes of cationic liposome-mediated gene delivery using human throat epidermis cancer cells
For studying the mechanism of cationic liposome-mediated transmembrane routes for gene delivery, various inhibitors of endocytosis were used to treat human throat epidermis cancer cells, Hep-2, before transfec...
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Development and characterization of a recombinant infectious bronchitis virus expressing the ectodomain region of S1 gene of H120 strain
Infectious bronchitis (IB), caused by infectious bronchitis virus (IBV), is a highly contagious chicken disease, and can lead to serious economic losses in poultry enterprises. The continual introduction of ne...
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Self-assembly of virus-like particles of canine parvovirus capsid protein expressed from Escherichia coli and application as virus-like particle vaccine
Canine parvovirus disease is an acute infectious disease caused by canine parvovirus (CPV). Current commercial vaccines are mainly attenuated and inactivated; as such, problems concerning safety may occur. To ...
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Virus-like particles in picornavirus vaccine development
Virus-like particles (VLP), which are similar to natural virus particles but do not contain viral genes, have brought about significant breakthroughs in many research fields because of their unique advantages....
