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  1. No Access

    Article

    Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice

    Mice lacking genes involving in the DNA-damage response (DDR) are often tumor prone owing to genome instability caused by oncogenic challenges. Previous studies demonstrate that activating transcription factor...

    Z Wang, Y He, W Deng, L Lang, H Yang, B **, R Kolhe, H-F Ding, J Zhang, T Hai… in Oncogene (2018)

  2. No Access

    Article

    Epithelial–mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways

    Epithelial–mesenchymal transition (EMT) is regarded as a crucial contributing factor to cancer progression. Diverse factors have been identified as potent EMT inducers in ovarian cancer. However, molecular mec...

    D Fang, H Chen, J Y Zhu, W Wang, Y Teng, H-F Ding, Q **g, S-B Su, S Huang in Oncogene (2017)

  3. No Access

    Article

    Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5+CK8+ epithelial cells

    Steroid sex hormones can induce prostate carcinogenesis, and are thought to contribute to the development of prostate cancer during aging. However, the mechanism for hormone-induced prostate carcinogenesis rem...

    Z Wang, J Kim, Y Teng, H-F Ding, J Zhang, T Hai, J K Cowell, C Yan in Oncogene (2016)

  4. No Access

    Article

    Loss of ATF3 promotes Akt activation and prostate cancer development in a Pten knockout mouse model

    Activating transcription factor 3 (ATF3) responds to diverse cellular stresses, and regulates oncogenic activities (for example, proliferation, survival and migration) through direct transcriptional regulation...

    Z Wang, D Xu, H-F Ding, J Kim, J Zhang, T Hai, C Yan in Oncogene (2015)

  5. Article

    Open Access

    Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation

    Embryonal cancer can arise from postnatally persistent embryonal remnant or rest cells, which are uniquely characterized by the absence of p53 mutations. Perinatal overexpression of the MycN oncoprotein in emb...

    M Calao, E O Sekyere, H J Cui, B B Cheung, W D Thomas, J Keating, J B Chen… in Oncogene (2013)

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  6. No Access

    Article

    Interleukin enhancer-binding factor 3 promotes breast tumor progression by regulating sustained urokinase-type plasminogen activator expression

    Sustained urokinase-type plasminogen activator (uPA) expression is detected in aggressive breast tumors. Although uPA can be transiently upregulated by diverse extracellular stimuli, sustained, but not transie...

    Q Hu, Y-Y Lu, H Noh, S Hong, Z Dong, H-F Ding, S-B Su, S Huang in Oncogene (2013)

  7. No Access

    Article

    Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression

    The Polycomb transcription repressor BMI1 is highly expressed in human neuroblastomas and is required for the clonogenic self-renewal and tumorigenicity of human neuroblastoma cell lines. The molecular basis o...

    L Mao, J Ding, A Perdue, L Yang, Y Zha, M Ren, S Huang, H Cui, H-F Ding in Oncogene (2012)