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  1. No Access

    Article

    Different allele distribution of a regulatory MAOA gene promoter polymorphism in antisocial and anxious-depressive alcoholics

    Heritable factors account for approximately 40–60% of the total variance of liability to alcohol dependence. The present study tested whether a novel functional polymorphism in the promotor region of the X-ch...

    L. G. Schmidt, T. Sander, S. Kuhn, M. Smolka… in Journal of Neural Transmission (2000)

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    Article

    Plasma levels of R- and S-salsolinol are not increased in "de-novo" Parkinsonian patients

    An augmented synthesis of tetrahydroisoquinolines, such as salsolinol (SAL) or an increased N-methylation of these compounds has been addressed by various investigators as putative pathophysiologic mechanisms...

    T. Müller, S. Sällström Baum, P. Häussermann, D. Woitalla… in Journal of Neural Transmission (1998)

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    Article

    Elevated levels of harman and norharman in cerebrospinal fluid of Parkinsonian patients

    Death of dopaminergic neurons in Parkinson's disease (PD) may partially be caused by synthesis and accumulation of endogenous and exogenous toxins. Because of structural similarity to MPTP, β-carbolines, like ...

    W. Kuhn, Th. Müller, H. Groβe, H. Rommelspacher in Journal of Neural Transmission (1996)

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    Article

    Evidence for prolonged recovery of dopaminergic transmission after detoxification in alcoholics with poor treatment outcome

    It has been hypothesized that dysfunction of dopaminergic neurotransmission is involved in the pathogenesis of alcohol addiction. Therefore, peripheral dopamine levels, sensitivity of central dopamine receptor...

    A. Heinz, B. Lichtenberg-Kraag… in Journal of Neural Transmission / General S… (1995)

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    Article

    [3H] UK-14,304, a new agonist ligand of α2-adrenoceptors: a comparative study with human and rat tissue

    [3H] UK-14,304 was used to investigateα 2-adrenoceptors in rat brain and human platelets. Receptor pharmacology revealed that the ligand binds with high affinity toα 2-adrenoceptors. Psychoactive substances like ...

    H. Rommelspacher, Sabine Strau\, E. FÄhndrich, H. J. Haug in Journal of Neural Transmission (1987)

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    Article

    Neuroleptics andβ-carbolines displace (3H)imipramine from its binding sites in human and rat tissues

    Most investigations dealing with the pharmacological characterization of (3H)imipramine binding sites focus on tricyclic antidepressants (TCA). This approach seemed to be justified since imipramine belongs to tha...

    H. Rommelspacher, Sabine Strauss in Journal of Neural Transmission (1985)

  7. No Access

    Article

    Effect of lesions of raphe nuclei on the activity of catecholaminergic and serotonergic neurones in various brain regions of the ratin vivo

    The dorsal raphe nucleus (DRN), the median raphe nucleus (MRN) and the B9 cell groups were lesioned separately. Then, the concentrations of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dopa...

    H. Rommelspacher, Sabine Strauss in Journal of Neural Transmission (1980)