17 Result(s)

Article

Different allele distribution of a regulatory MAOA gene promoter polymorphism in antisocial and anxious-depressive alcoholics

Heritable factors account for approximately 40–60% of the total variance of liability to alcohol dependence. The present study tested whether a novel functional polymorphism in the promotor region of the X-ch...

L. G. Schmidt, T. Sander, S. Kuhn, M. Smolka… in Journal of Neural Transmission (2000)

Article

Gamma-Hydroxybuttersäure zur Therapie des Alkoholentzugssyndroms bei Intensivpatienten Vergleich zweier symptomorientierter therapeutischer Konzepte

Gamma-Hydroxybuttersäure (GHB) und Benzodiazepine interagieren beide mit dem gabaergen Transmittersystem. Vergleichend wurden sie zur intravenösen Therapie des Alkoholentzugssyndroms bei Patienten einer interd...

E. Lenzenhuber, C. Müller, H. Rommelspacher, C. Spies in Der Anaesthesist (1999)

Article

Plasma levels of R- and S-salsolinol are not increased in "de-novo" Parkinsonian patients

An augmented synthesis of tetrahydroisoquinolines, such as salsolinol (SAL) or an increased N-methylation of these compounds has been addressed by various investigators as putative pathophysiologic mechanisms...

T. Müller, S. Sällström Baum, P. Häussermann, D. Woitalla… in Journal of Neural Transmission (1998)

Article

Elevated levels of harman and norharman in cerebrospinal fluid of Parkinsonian patients

Death of dopaminergic neurons in Parkinson's disease (PD) may partially be caused by synthesis and accumulation of endogenous and exogenous toxins. Because of structural similarity to MPTP, β-carbolines, like ...

W. Kuhn, Th. Müller, H. Groβe, H. Rommelspacher in Journal of Neural Transmission (1996)

Article

Poster Discussions

M. M. Berger, M. J. Reymond, A. Shenkin, C. A. Wardle, F. Rey… in Intensive Care Medicine (1996)

Article

Intercurrent complications in chronic alcoholic men admitted to the intensive care unit following trauma

A chronic alcoholic group following trauma was investigated to determine whether their ICU stay was longer than that of a non-alcoholic group and whether their intercurrent complication rate was increased

C. D. Spies, B. Neuner, T. Neumann, S. Blum, C. Müller… in Intensive Care Medicine (1996)

Article

Evidence for prolonged recovery of dopaminergic transmission after detoxification in alcoholics with poor treatment outcome

It has been hypothesized that dysfunction of dopaminergic neurotransmission is involved in the pathogenesis of alcohol addiction. Therefore, peripheral dopamine levels, sensitivity of central dopamine receptor...

A. Heinz, B. Lichtenberg-Kraag… in Journal of Neural Transmission / General S… (1995)

Article

Der Stellenwert des kohlenhydratdefizienten Transferrin (CDT)

Alkoholkranke Patienten sind in der postoperativen Phase auf der Intensivstation durch die Dekompensation alkoholismusinduzierter Folgeerkrankungen vital bedroht. Vor allem das Alkoholentzugssyndrom (AES) pro...

Th. Heil, C. Spies, C. Bullmann, T. Neumann, K. Eyrich, C. Müller… in Der Anaesthesist (1994)

Article

[³H]norharman ([³H]β-carboline) binds reversibly and with high affinity to a specific binding site in rat liver

In addition to the known binding of norharman (NH) to monoamine oxidase (MAO) and benzodiazepine (BZ) binding sites (at μM concentrations), a distinct class of high-affinity NH binding sites was discovered in ...

A. Greube, H. Rommelspacher in Neurochemical Research (1993)

Article

[³H] UK-14,304, a new agonist ligand of α₂-adrenoceptors: a comparative study with human and rat tissue

[³H] UK-14,304 was used to investigateα ₂-adrenoceptors in rat brain and human platelets. Receptor pharmacology revealed that the ligand binds with high affinity toα ₂-adrenoceptors. Psychoactive substances like ...

H. Rommelspacher, Sabine Strau\, E. FÄhndrich, H. J. Haug in Journal of Neural Transmission (1987)

Article

Diazepam attenuates the antagonism of haloperidol against apomorphine-induced stereotypic behavior after subchronic but not acute treatment in rats

Apomorphine-induced stereotypic behavior was investigated in rats treated with diazepam or haloperidol and with the combination of both drugs in a one day trial or subchronically. The drugs were administered v...

V. Fuchs, H. Coper, S. Strauß… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1986)

Article

Neuroleptics andβ-carbolines displace (³H)imipramine from its binding sites in human and rat tissues

Most investigations dealing with the pharmacological characterization of (³H)imipramine binding sites focus on tricyclic antidepressants (TCA). This approach seemed to be justified since imipramine belongs to tha...

H. Rommelspacher, Sabine Strauss in Journal of Neural Transmission (1985)

Article

Effect of lesions of raphe nuclei on the activity of catecholaminergic and serotonergic neurones in various brain regions of the ratin vivo

The dorsal raphe nucleus (DRN), the median raphe nucleus (MRN) and the B9 cell groups were lesioned separately. Then, the concentrations of 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), dopa...

H. Rommelspacher, Sabine Strauss in Journal of Neural Transmission (1980)

Article

Pharmacological properties of tetrahydronorharmane (Tryptoline)

Earlier in vitro experiments led to the hypothesis that tetrahydronorharmane (THN) modulates the effect of serotonin. This assumption has now been tested in vivo on rats. In addition dopaminergic mechanisms we...

H. Rommelspacher, H. Kauffmann… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1977)

Article

Inhibition of the reuptake of serotonin by tryptoline

Tryptoline, a metabolite of tryptamine, competitively inhibits serotonin accumulation in nuclei-free homogenate of rat “forebrains”. After intraventricular injection the drug elicits an increase of serotonin l...

H. Rommelspacher, P. Bade, H. Coper… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1976)

Article

The influence of adrenergic receptor-blocking agents, amphetamine, and 6-aminonicotinamide on thermoregulation

The influence ofα- andΒ-receptor-blocking agents, as well as that of amphetamine and of 6-aminonicotinamide (6-AN) on the body temperature of the rat was examined at three different ambient temperatures (AT). The...

H. Coper, H. Lison, H. Rommelspacher… in Naunyn-Schmiedebergs Archiv für Pharmakolo… (1971)