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Article
Open AccessStructural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor
The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The 26RFa/QRFPR system plays critical roles in energy homeosta...
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Article
Open AccessComprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities
Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We performed large-scale pro...
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Article
Open AccessLysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance
Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation modifications remain unknown. Chemoresistance remains a daunting challe...
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Article
Open AccessAuthor Correction: Discovery of new genetic loci for male sexual orientation in Han population
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Open AccessDiscovery of new genetic loci for male sexual orientation in Han population
Epidemiological studies have demonstrated that the genetic factors partly influence the development of same-sex sexual behavior, but most genetic studies have focused on people of primarily European ancestry, ...
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Article
Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
The antimalarial drug artemisinin and its derivatives have been explored as potential anticancer agents, but their underlying mechanisms are controversial. In this study, we found that artemisinin compounds ca...
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Article
Open AccessIRF4 is a novel mediator for neuronal survival in ischaemic stroke
Neuroprotection following ischaemic stroke is driven by the interplay between regulatory transcription factors and endogenous protective factors. IRF4, a member of the interferon regulatory factor (IRF) family...