5 Result(s)
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Article
A synthetic peptide derived from mouse pituitary calcitonin cDNA sequence exhibits potent inhibition of prolactin secretion and prolactin mRNA abundance in primary mouse pituitary cells
We have shown that gonadotrophs synthesize and secrete immunoreactive calcitonin (CT)-like peptide, and CT is a potent inhibitor of prolactin (PRL) secretion and gene transcription. CT cDNA cloned from LßT2 ce...
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Article
Calcitonin inhibits prolactin promoter activity in rat pituitary GGH3 cells
Previous findings from our laboratory have shown that pituitary calcitonin-like peptide (pit-CT) is synthesized and released by gonadotrophs and inhibits prolactin (PRL) release, synthesis, and lactotroph prol...
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Article
Calcitonin-like peptide containing gonadotrophs are juxtaposed to cup-shaped lactotrophs
Calcitonin (CT) is known to inhibit basal and TRH-stimulated prolactin release in cultured anterior pituitary cells in vitro and pituitary CT-like peptide (pit-CT) is synthesized and released by isolated anter...
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Article
Estrogen attenuates expression of calcitonin-like immunoreactivity in the anterior pituitary gland
Estrogens increase prolactin (PRL) synthesis and release in rats and humans, whereas pituitary-derived calcitonin-like immunoreactive peptide (pit-CT) inhibits PRL gene expression and release. To test the hypo...
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Article
Calcitonin inhibits prolactin gene transcription in rat pituitary cells
Our recent studies have shown that calcitonin (CT)-like immunoreactive peptide is synthesized and released from cultured rat anterior pituitary (AP) cells, and may serve as a paracrine inhibitor of PRL release...
