10 Result(s)
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Gavin M. Douglas
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Article
Pseudogenes act as a neutral reference for detecting selection in prokaryotic pangenomes
A long-standing question is to what degree genetic drift and selection drive the divergence in rare accessory gene content between closely related bacteria. Rare genes, including singletons, make up a large pr...
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Open AccessAuthor Correction: Microbiome differential abundance methods produce different results across 38 datasets
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Open AccessMicrobiome differential abundance methods produce different results across 38 datasets
Identifying differentially abundant microbes is a common goal of microbiome studies. Multiple methods are used interchangeably for this purpose in the literature. Yet, there are few large-scale studies systema...
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Open AccessRe-evaluating the relationship between missing heritability and the microbiome
Human genome-wide association studies (GWASs) have recurrently estimated lower heritability estimates than familial studies. Many explanations have been suggested to explain these lower estimates, including th...
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PICRUSt2 for prediction of metagenome functions
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Author Correction: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
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Open AccessEnhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in human health and disease remain el...
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Open AccessMulti-omics differentially classify disease state and treatment outcome in pediatric Crohn’s disease
Crohn’s disease (CD) has an unclear etiology, but there is growing evidence of a direct link with a dysbiotic microbiome. Many gut microbes have previously been associated with CD, but these have mainly been c...
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The coupling of taxonomy and function in microbiomes
Microbiologists are transitioning from the study and characterization of individual strains or species to the profiling of whole microbiomes and microbial ecology. Equipped with high-throughput methods for stu...
