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  1. Article

    Open Access

    Selecting the optimal position of CDK4/6 inhibitors in hormone receptor-positive advanced breast cancer – the SONIA study: study protocol for a randomized controlled trial

    Combining cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors with endocrine therapy is an effective strategy to improve progression-free survival in hormone receptor-positive (HR+), human epidermal growth fa...

    A. van Ommen-Nijhof, I. R. Konings, C. J. J. van Zeijl, C. A. Uyl-de Groot… in BMC Cancer (2018)

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  2. Article

    Open Access

    Study protocols of three parallel phase 1 trials combining radical radiotherapy with the PARP inhibitor olaparib

    Poly (ADP-ribose) Polymerase (PARP) inhibitors are promising novel radiosensitisers. Pre-clinical models have demonstrated potent and tumour-specific radiosensitisation by PARP inhibitors. Olaparib is a PARP i...

    R. de Haan, E. van Werkhoven, M.M. van den Heuvel, H. M. U. Peulen… in BMC Cancer (2019)

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