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  1. No Access

    Article

    Development of a bioartificial liver employing xenogeneic hepatocytes

    Liver failure is a major cause of mortality. A bioartificial liver (BAL) employing isolated hepatocytes can potentially provide temporary support for liver failure patients. We have developed a bioartificial l...

    Wei-Shou Hu, Julie R. Friend, Florence J. Wu, Timothy Sielaff… in Cytotechnology (1997)

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    Article

    Mechanistics of formation and ultrastructural evaluation of hepatocyte spheroids

    Freshly harvested rat hepatocytes form spheroids on uncoated positively charged polystyrene surfaces. Time lapse microscopy revealed that cell movement and reorganization were involved in spheroid formation. U...

    Madhusudan V. Peshwa, Florence J. Wu… in In Vitro Cellular & Developmental Biology … (1996)

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    Article

    Extended liver-specific functions of porcine hepatocyte spheroids entrapped in collagen gel

    The potential use of porcine hepatocytes in a bioartificial liver device requires large quantities of viable and highly active cells. To facilitate the scaling up of the system, liver specific activities of he...

    Arye Lazar, Henry J. Mann, Rory P. Remmel… in In Vitro Cellular & Developmental Biology … (1995)

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    Article

    A sensitive measurement of oxygen uptake rate using a optochemical sensor

    The measurement of the specific oxygen uptake rate (OUR) of slow growing organisms using a small sample size is often hampered by the consumption of oxygen by the electrode used. Using a optochemical sensor we...

    Chung-Ming Chi, Leah N. Frautschy, Frank B. Cerra, Wei-Shou Hu in Biotechnology Techniques (1993)

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    Article

    Primary culture of rat hepatocytes entrapped in cylindrical collagen gels: An in vitro system with application to the bioartificial liver

    A static culture model employing cylindrical collagen-hepatocyte gels is reported for large scale testing of conditions relevant to the three compartment hollow fiber bioartificial liver. High density hepatocy...

    Scott L. Nyberg, Russell A. Shatford, William D. Payne, Wei-Shou Hu… in Cytotechnology (1992)

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    Article

    Microelectrode measurement of oxygen tensions in collagen-hepatocyte gels

    Microelectrodes have been used for the measurement of oxygen tension in various biological systems.(Silver, 1987) Although not previously reported, microelectrodes allow the direct measurement of oxygen tensio...

    Scott L. Nyberg, Steven M. Santilli, Russell A. Shatford… in Biotechnology Techniques (1991)

  7. Article

    AMINO ACIDS IN INFANTS WITH NON-CORRECTED EXTRA-HEPATIC BILIARY ATRESIA (EBA)

    Feeding formulations which are enriched in branch chain amino acids (BCAA) and depleted in aromatic amino acids (AAA) and methionine (Met) are used in therapy of adults with hepatic encephalopathy (HE). These ...

    Sally A Weisdorf, John Fath, Deborah K Freese, Frank B Cerra in Pediatric Research (1984)

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    Article

    Arterial embolization for traumatic hemobilia with hepato-portal fistula

    A case of blunt liver trauma complicated by delayed upper gastrointestinal bleeding, probably hemobilia, was successfully treated by intra-arterial embolization. Laparotomy with liver resection or hepatic arte...

    Sadashiv S. Shenoy M.D., Jacob Bergsland… in CardioVascular and Interventional Radiology (1981)