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Engineered Extracellular Vesicles as a Targeted Delivery Platform for Precision Therapy

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  1. Article

    Open Access

    Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration

    Photoreceptor apoptosis is an important pathogenesis of retinal degeneration and a primary cause of vision loss with limited treatment methods. Mesenchymal stem/stromal cells-derived small extracellular vesicl...

    Yuntong Sun, Yuntao Sun, Shenyuan Chen, Yifan Yu… in Journal of Nanobiotechnology (2023)

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  2. Article

    Open Access

    Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4

    As a leading cause of vision decline and severe blindness in adults, diabetic retinopathy (DR) is characterized by the aggravation of retinal oxidative stress and apoptosis in the early stage. Emerging studies...

    Fengtian Sun, Yuntong Sun, Junyan Zhu, **aoling Wang… in Stem Cell Research & Therapy (2022)

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  3. Article

    Open Access

    Exosomes derived from hucMSC attenuate renal fibrosis through CK1δ/β-TRCP-mediated YAP degradation

    Exosomes from human umbilical cord mesenchymal stem cells (hucMSC-Ex) have been suggested as novel nanomaterials for regenerative medicine. Here we explored the roles of hucMSC-Ex through regulating Yes-associ...

    Cheng Ji, Jiahui Zhang, Yuan Zhu, Hui Shi, Siqi Yin, Fengtian Sun… in Cell Death & Disease (2020)

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