5 Result(s)
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Article
Esmerilda G. Delicado
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Article
Open AccessDUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden
The P2X7 receptor (P2X7R) stands out within the purinergic family as it has exclusive pharmacological and regulatory features, and it fulfills distinct roles depending on the type of stimulation and cellular e...
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Open AccessP2X7, NMDA and BDNF receptors converge on GSK3 phosphorylation and cooperate to promote survival in cerebellar granule neurons
Glycogen synthase kinase-3 (GSK3) is a key player in the regulation of neuronal survival. Herein, we report evidence of an interaction between P2X7 receptors with NMDA and BDNF receptors at the level of GSK3 s...
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Open AccessP2X7 Nucleotide Receptor is Coupled to GSK-3 Inhibition and Neuroprotection in Cerebellar Granule Neurons
In this study we report the coupling of nucleotide receptors to GSK-3 signalling, a relevant survival pathway in cerebellar granule neurons. P2X7 agonist BzATP induced a 3–4-fold increase in GSK-3 phosphorylation...
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Dinucleoside polyphosphates and their interaction with other nucleotide signaling pathways
Dinucleoside polyphosphates or ApnA are a family of dinucleotides formed by two adenosines joined by a variable number of phosphates. Ap4A, Ap5A, and Ap6A are stored together with other neurotransmitters into sec...
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Modulation of the kinetic characteristics of the sarcoplasmic reticulum ATPase by membrane fluidity
(Ca2+ + Mg2+)-ATPase from sarcoplasmic reticulum has been reconstituted with dipalmitoylphosphatidylcholine, and the activating effect of ATP and Ca2+ on this enzyme has been studied at different temperatures. It...
